At least two separate inhibitory actions on 5-HT3A receptors could be identified for propofol, whereas the enhancing action seen for the two related smaller phenol derivatives could no longer be detected. 5-HT-dependent and 5-HT-independent interactions could be distinguished for all three drugs. Propofol was less potent than expected from its hydrophobic properties. Underlying mechanisms appear to involve the phenolic hydroxyl group, hydrophobic interactions, and steric restrictions.

No abstract

Although very simple and elegant, Linda-style coordination models lack the notion of time, and are therefore not able to precisely model real-life coordination applications. Nevertheless, industrial proposals such as TSpaces and JavaSpaces, inspired from Linda, have incorporated time constructs. This paper aims at a systematic study of the introduction of relative time in coordination models. It builds upon previous work to study the expressiveness of Linda, Linda extended with a delay mechanism and Linda primitives extended to support the duration of tuples and of the suspension of communication operations.

Although very simple and elegant, Linda-style coordination models lack the notion of time, and are therefore not able to precisely model real-life coordination applications. Nevertheless, industrial proposals such as TSpaces and JavaSpaces, inspired from Linda, have incorporated time constructs. This paper aims at a systematic study of the introduction of relative time in coordination models. It builds upon previous work to study the expressiveness of Linda, Linda extended with a delay mechanism and Linda primitives extended to support the duration of tuples and of the suspension of communication operations.

No abstract