This article presents microneedles analyses where the design parameters studied included length and inner and outer diameter ranges. A mathematical model was also used to generalize outer and inner diameter ratios in the obtained ranges. Following this, the range of inner and outer diameters was completed by mechanical simulations, ranging from 30 μm to 134 μm as the inner diameter range and 208 μm to 250 μm as the outer diameter range. With these ranges, a mathematical model was made using fourth-order polynomial regressions with a correlation of 0.9993, ensuring a safety factor of four in which von Misses forces of the microneedle are around 17.931 MPa; the ANSYS software was used to analyze the mechanical behavior of the microneedles. In addition, the microneedle concept was made by 3D printing using a bio-compatible resin of class 1. The features presented by the microneedle designed in this study make it a promising option for implementation in a transdermal drug-delivery device.
Diabetes mellitus is an endocrine disorder that affects glucose metabolism, making the body unable to effectively use the insulin it produces. Transdermal drug delivery (TDD) has attracted strong interest from researchers, as it allows minimally invasive and painless insulin administration, showing advantages over conventional delivery methods. Systems composed of microneedles (MNs) assembled in a transdermal patch provide a unique route of administration, which is innovative with promising results. This paper presents the design of a transdermal patch composed of 25 microneedles manufactured with 3D printing by stereolithography with a class 1 biocompatible resin and a printing angle of 0°. Finite element analysis with ANSYS software is used to obtain the mechanical behavior of the microneedle (MN). The values obtained through the analysis were: a Von Misses stress of 18.057 MPa, a maximum deformation of 2.179×10−3, and a safety factor of 4. Following this, through a flow simulation, we find that a pressure of 1.084 Pa and a fluid velocity of 4.800 ms were necessary to ensure a volumetric flow magnitude of 4.447×10−5cm3s. Furthermore, the parameters found in this work are of great importance for the future implementation of a transdermal drug delivery device.
This article presents the microneedles analysis where the design parameters studied were length, inner and outer diameter range. The ANSYS software was used to analyze the mechanical behavior of the microneedles. Following this, the range of inner and outer diameters were completed by mechanical simulations, getting from 30 μm to 134 μm, as the inner diameter range and 208 μm to 250 μm as the outer diameter range. With these ranges, a mathematical model was made using fourth-order polynomial regression, with a correlation of 0,9993. This mathematical model generalizes the relationship of the inner diameter to the outer diameter within the ranges, ensuring a safety factor of four, where Von Misses forces of the microneedle are around 17.931 MPa. In addition, the microneedle concept was made by 3D printing using a biocompatible resin of class 1. The features presented by the microneedle designed in this work make it a promising option to be implemented in a transdermal drug delivery device.
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