The chemoenzymatic high molecular weight (ca. 20,000 Da) poly-L-phenylalanine (ePLP) self-assembly behavior and the nano-morphologies thereof are investigated. Interestingly, this supramolecular ePLP changes from a non-ordered secondary structure when solubilized...
Chemoenzymatic polypeptide synthesis offers several advantages over chemical or other biological routes, however, the use of aqueous-based media suffers from reverse hydrolysis reactions that challenge peptide chain propagation.
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