SUMMARY BackgroundThe response rate to hepatitis B virus (HBV) vaccination in patients with inflammatory bowel disease (IBD) is low.

The application of these recommendations will facilitate the dermatologist practice and benefit HS patients' health and quality of life.

Since its first identification in China in December 2019, several reports have been published describing epidemiological and clinical characteristics of patients with COVID-19, with an overall mortality rate ranging from 1.4% to 2.3%, that can increase up to 22.4%-24.5% in hospitalized patients. 2,3 Patients with cancer have a higher susceptibility to infections due to their immunosuppression state caused by the malignancy itself or by antineoplastic treatments. Specifically, infections caused by community respiratory viruses had been associated with poor outcome in patients with hematological malignancies. Few data are available on hematologic patients and COVID-19 infection, with discordant results, probably due to the small sample size of the studies. To date, these data come from retrospective clinical case series 4-9 from different countries in which case fatality rates (CFR) range from 33% to 62%. Mortality has been associated, depending on the published series, with age, comorbidities, active hematological disease, intensive treatment, or some laboratory variables. Thus, more data are required to better characterize the real impact of COVID-19 in patients with hematological neoplasms, in order to optimize clinical decision-making. We carried out a single-center analysis of 41 consecutive patients with hematological malignancies who developed COVID-19 between March 8 and

Background Post-marketing data are required to confirm the durability and the long-term benefit and safety of UST in CD in clinical practice. Our aims were: (1) to evaluate the retention rate of UST in CD patients and to identify predictive factors of UST discontinuation; (2) to assess UST short-term effectiveness; (3) to analyse the durability of the response to UST in the long-term; and (4) to evaluate the safety of UST in clinical practice. Methods Retrospective, multicentre study (>60 centres). Patients with active CD [(Harvey–Bradshaw (HBI) >4)] that received at least one dose of UST intravenously before July 2018 were included. Clinical activity plus biochemical parameters were assessed at every UST administration. Clinical remission was defined as HBI score ≤4, and clinical response as a decrease in HBI ≥3 points. Loss of efficacy was defined as reappearance of symptoms that led to intensify the treatment dose, add another medication to control CD, switching or surgery in patients with short-term remission. The retention rate of UST treatment and the cumulative incidence of loss of efficacy were evaluated by survival curves, and predictive factors were assessed by Cox-regression. The short-term response was evaluated at week 8 and after the induction (week 16). Factors associated with short-term remission were assessed by multivariate analysis. Adverse events were recorded. Data quality was assured by remote monitoring. Results 331 CD patients have been included up to date (Table 1). The incidence rate of UST discontinuation was 15% per patient-year of follow-up: 8%, 13% and 20% at 6, 12 and 18 months (Figure 1). Previous surgery was the only factor associated with a higher risk of UST discontinuation [Hazard ratio (HR) = 2.03, 95% confidence interval (CI) = 1.1–3.6]. Short-term efficacy is shown in Figure 2. Previous surgery (OR = 0.3, 95% CI = 0.2–0.6) and higher HBI score at baseline (OR = 0.8, 95% CI=0.8–0.9) were associated with an impaired response to UST at week 16. The cumulative incidence of loss of response was 32% per-patient-year of follow-up (Figure 3); A higher HBI score at baseline was associated with a higher risk of losing response (HR = 1.2, 95% CI = 1.1–1.3). Neither the concomitant treatment with immunosuppressants nor the number of previous biologics were associated with UST short- and long-term benefit. Thirty adverse events were reported in 25 (7%) patients (Table 2). Conclusion Sustain is the largest real clinical practice study of UST to treat CD patients with the longest follow-up reported to date. UST was demonstrated to be effective in real-world use in the short and long run. Safety was consistent with the known profile of UST.