We characterised and reported the first full-length genomes of Human T-cell
Lymphotropic Virus Type 1 subgroup HTLV-1aD (CV21 and CV79). This subgroup is one of
the major determinants of HTLV-1 infections in North and West Africa, and recombinant
strains involving this subgroup have been recently demonstrated. The CV21 and CV79
strains from Cape Verde/Africa were characterised as pure HTLV-1aD genomes,
comparative analyses including HTLV-1 subtypes and subgroups revealed HTLV-1aD
signatures in the envelope, pol, and pX regions. These genomes provide original
information that will contribute to further studies on HTLV-1a epidemiology and
evolution.
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