Cross-reactivity in the Platelia Aspergillus enzyme immunoassay was evaluated using 120 sera from patients with paracoccidioidomycosis, histoplasmosis, and cryptococcosis. At a cutoff value of 0.5, positivity rates were 50%, 67%, and 50%, respectively. The implications for these findings are discussed.

We present a case of sphenoid sinus fungus ball caused by Aspergillus fumigatus associated with actinomycosis. This case represents the first known reported infection caused by this rare association.

Descrevemos 27 casos de rinossinusite fúngica causada por agentes não aspergilares diagnosticados em nossa instituição durante um período de 24 anos. O foco do estudo foi o agente causal e fatores predisponentes. Em 20 casos foi isolado o agente fúngico e, em 7, não houve crescimento. A rinossinusite foi classificada em invasiva e não invasiva com base em avaliação clínica, radiológica e histopatológica. Os agentes patogénicos mais comuns foram Histoplasma capsulatum (n = 4), Scedosporium apiospermum (n = 2), Alternaria alternata (n = 2), Schizophyllum commune (n = 2), Pseudallescheria boydii (n = 1), Penicillium sp (n=1), Lichtheimia (Absidia) corymbifera (n = 1), Xylaria enteroleuca (n = 1), Trichoderma asperellum (n = 1), T. harzianum (n = 1), T. viride (n = 1), Fusarium solani (n = 1), Cladosporium sp (n = 1) e Cryptococcus neoformans (n = 1). Os casos em que não ocorreu crescimento foram classificados, com base nos achados histopatológicos, como hialohifomicose (n = 4) e mucormicose (n = 3). Além disso, descrevemos o primeiro caso de rinossinusite humana pelo T. asperellum.

Aspergillosis of the nose and paranasal sinuses: a review of 54 cases Aspergillus species are considered opportunistic fungi of increasing clinical importance. Information regarding extrapulmonary involvement is scarce. The aim of this study was to isolate the different species of Aspergillus from patients with rhinosinusitis. A retrospective study was conducted in a university hospital in Porto Alegre, Brazil (1986-2014. For mycological diagnoses, paranasal tissue obtained at surgery was subjected to histopathology examination and sent for fungal cultures. Of the 54 samples analyzed, 32 were diagnosed positive by culture. The underlying causes of immunodeficiency were: six with transplantation (three bone marrow,two lung, one kidney) and two with hematological disease (one bone marrow neoplasia and two leukemia). In the present study, the clinical manifestations of rhinosinusitis aspergillosis were: 20 allergic reactions, 20 fungus balls, and 14 acute invasive cases. The species isolated from the 54 samples were: Aspergillus fumigatus (n=14); A. flavus (n=6); A. niger (n=2); A. terreus (n=1); A. fischeri (n=1); and Aspergillus sp., (n=3). Two concomitant species of Aspergillus were observed in two patients: A. fumigatus and A. flavus; and A. fumigatus and A. niger. In four patients, Aspergillus was associated with other