The controlled release of functionally active compounds is important in a variety of applications. Here, we have synthesized, characterized, and studied the magnetic properties of three novel metal−metal-bonded tris(formamidinato) Ru 2 5+ complexes. We have used different auxin-related hormones, indole-3-acetate (IAA), 2,4-dichlorophenoxyacetate (2,4-D), and 1-naphthaleneacetate (NAA), to generate [Ru 2 Cl(μ-DPhF) 3 (μ-IAA)] (RuIAA), [Ru 2 Cl(μ-DPhF) 3 (μ-2,4-D)] (Ru2,4-D), and [Ru 2 Cl(μ-DPhF) 3 (μ-NAA)] (RuNAA) (DPhF = N,N′-diphenylformamidinate). The crystal structures of RuIAA, RuIAA•THF, Ru2,4-D•CH 2 Cl 2 , and RuNAA•0.5THF have been determined by single-crystal Xray diffraction. To assess the releasing capacity of the bound hormone, we have employed a biological assay that relied on Arabidopsis thaliana plants expressing an auxin reporter gene and we demonstrate that the release of the phytohormones from RuIAA, Ru2,4-D, and RuNAA is pH-and time-dependent. These studies serve as a proof of concept showing the potential of these types of compounds as biological molecule carriers.
The controlled release of biologically active species from diruthenium compounds is crucial for the development of selective drug delivery systems based on such complexes, which in addition display antineoplastic properties...
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