Depression is considered the most important disorder affecting mental health. The aim of this systematic integrative review was: (i) to describe the effects of supplementation with adaptogens on variables related to depression in adults; and (ii) to discuss the potential combination with physical exercise to aid planning and commissioning future clinical research. An integrative review was developed complementing the Preferred Reporting Items for Systematic reviews and Meta-Analyses statement (PROSPERO registration: CRD42021249682). A total of 41 articles met the inclusion criteria. With a Price index of 46.4%, we found that: (i) Hypericum perforatum (St. John’s Wort) is the most studied and supported adaptogen (17/41 [41.46%], three systematic reviews with meta-analysis) followed by Crocus sativus L. or saffron (6/41 [14.63%], three systematic reviews with meta-analysis and two systematic reviews); (ii) it is possible that the significantly better performance of adaptogens over placebo is due to the reduction of allostatic load via the action of secondary metabolites on BDNF regulation; and, (iii) the number of studies reporting physical activity levels is limited or null for those that combine an exercise program with the consumption of adaptogens. Aware of the need for a multidisciplinary approach for depression treatment, this systematic integrative review provides an up-to-date view for supporting the use of St. John’s Wort and saffron as non-pharmacological strategies while also help commissioning future research on the efficacy of other adaptogens. It also contributes to the design of future clinical research studies that evaluate the consumption of herbal extracts plus physical exercise, mainly resistance training, as a potentially safe and powerful strategy to treat depression.
El objetivo del estudio fue reportar los valores de referencia para el VO2máx indirecto obtenido en las pruebas de Cooper Run Test (CRT) y Shuttle Run Test (SRT-20m) en población adulta entrenada que reside a una altitud entre los 2600 y 3700 msnm. Un total de 614 sujetos físicamente activos (118 mujeres, 496 hombres; 20.2±2.3 años; 65.3±10.3 kg; 169.1 ± 7.8 cm; 22.7±2.8 kg·m-2) residentes en la ciudad de Bogotá, o municipios del área metropolitana, participaron en este estudio de tipo descriptivo transversal. Se establecieron los percentiles de VO2máx para las pruebas CRT y SRT-20m en la población de estudio, resaltando que los registros obtenidos en el SRT-20m fueron mayores que CRT. Los valores de VO2máx en los sujetos que habitan a <3000 msnm fueron menores en comparación con los residentes a 3001 – 4000 msnm (p=0.01); asimismo, las mujeres reportaron un menor nivel de aptitud física cardiorrespiratoria (AFC) que los hombres (p<0.01). En conclusión, estos valores reportados pueden ser empleados para la evaluación de la AFC de poblaciones con características similares. Por otra parte, las variaciones encontradas en los valores de VO2máx podrían estar asociadas a variantes genéticas (e.g. polimorfismos) o a las adaptaciones propias del entrenamiento (e.g., especificidad del entrenamiento, técnica de carrera); no obstante, se requiere más investigación sobre estos aspectos en este tipo de población.
The academic curriculum has shown to promote sedentary behavior in college students. This study aimed to profile the physical fitness of physical education majors using unsupervised machine learning and to identify the differences between sexes, academic years, socioeconomic strata, and the generated profiles. A total of 542 healthy and physically active students (445 males, 97 females; 19.8 [2.2] years; 66.0 [10.3] kg; 169.5 [7.8] cm) participated in this cross-sectional study. Their indirect VO2max (Cooper and Shuttle-Run 20 m tests), lower-limb power (horizontal jump), sprint (30 m), agility (shuttle run), and flexibility (sit-and-reach) were assessed. The participants were profiled using clustering algorithms after setting the optimal number of clusters through an internal validation using R packages. Non-parametric tests were used to identify the differences (p < 0.05). The higher percentage of the population were freshmen (51.4%) and middle-income (64.0%) students. Seniors and juniors showed a better physical fitness than first-year students. No significant differences were found between their socioeconomic strata (p > 0.05). Two profiles were identified using hierarchical clustering (Cluster 1 = 318 vs. Cluster 2 = 224). The matching analysis revealed that physical fitness explained the variation in the data, with Cluster 2 as a sex-independent and more physically fit group. All variables differed significantly between the sexes (except the body mass index [p = 0.218]) and the generated profiles (except stature [p = 0.559] and flexibility [p = 0.115]). A multidimensional analysis showed that the body mass, cardiorespiratory fitness, and agility contributed the most to the data variation so that they can be used as profiling variables. This profiling method accurately identified the relevant variables to reinforce exercise recommendations in a low physical performance and overweight majors.
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