The sodium salt of N-dichloroacetyl-DL-serine depresses the growth of sarcoma-37 in mice, causing complete regressions of the tumor. The compound is nontoxic to mice in doses up to 4 gm/kg of body weight. The animals do not lose body weight and show no alteration in the formed elements of the blood or in hemoglobin content.
It was observed that when very dilute solutions of hydrogen peroxide were employed for the purpose of destroying pyrogens in aqueous dextran solutions, a marked depolymerization of the polysaccharide molecule occurred. Further study demonstrated this effect to occur over a wide range of temperature, pressure, time, and concentration of hydrogen peroxide. It was therefore possible to use hydrogen peroxide in place of the usual hydrolytic agents, such as acids, for the depolymerization of native dextran to smaller molecular weight fragments suitable for use as a blood plasma extender.
It was observed that when very dilute solutions of hydrogen peroxide were employed for the purpose of destroying pyrogens in aqueous dextran solutions, a marked depolymerization of the polysaccharide molecule occurred. Further study demonstrated this effect to occur over a wide range of temperature, pressure, time, and concentration of hydrogen peroxide. It was therefore possible to use hydrogen peroxide in place of the usual hydrolytic agents, such as acids, for the depolymerization of native dextran to smaller molecular weight fragments suitable for use as a blood plasma extender.
It has been demonstrated in preliminary experiments that two strains of rat tumor cells (WRC-256 and TSAT-72) utilize alpha-2-globulin more selectively than other protein components of human serum. Cells of strain TSAT-72 show some utilization of beta-globulins also. Separate experiments demonstrated the utilization of glycoproteins by both strains.
Vol. 65insoluble product not being obtained by re-ethanolysis of 3 mafile ether-soluble lignin.As in the case of maple lignin, the water-soluble spruce lignin (G') could be separated into a petroleum etherinsoluble (J') and a petroleum ether-soluble (K') fraction and the latter separated further into a bisulfite (L'), an acid (M'), an alkali (N') and a neutral (0') fraction.From the bisulfite and alkali fractions 1-(4-hydroxy-3methoxyphenyl)-1,2-propanedione and Z-ethoxy-l-(4-hydroxy-3-methoxyphenyl)-l-propanone, respectively, were isolated and identified by the usual methods.3 Thus re-ethanolysis of both spruce and maple ethanol lignin fractions yields the same products as isolated by use of the standard wood ethanolysis procedure and there would seem to be no doubt but that the extraction of lignin by the action of ethanolic hydrogen chloride involves the previously-discussed' concurrent polymerization-depolymerization changes. The amount of polymerization is evidently greater, and the depolymerization less, in spruce (a gymnosperm) than in maple (an angiospermi. The fact that l-(4-hydroxy-3-methoxyphenyl)-l,2-propanedione and 2-ethoxy-l-(4-hydroxy-3-methoxyphenyl)-1-propanone from spruce wood and these two derivatives together with their 4-hydroxy-3,5-dimethoxyphenyl honiologs from maple wood are the only, as yet, isolable cleavage products of each ethanol lignin fraction indicates that they are either primary cleavage products or, as now seems ____-___1180 &MARSHALL KULKA AND HAROLD HIEBERT Vol. 65
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