Lanthanum Zirconate nanoparticles (NPs) are used in blades of gas turbine engines to thermally insulate them and to protect them against hot and corrosive gas streams. However, the information regarding their biocompatibility is limited. The present study was aimed to report the effect of Lanthanum Zirconate NPs on selected aspects of behavior, serum biochemistry, complete blood count and antioxidant parameters from vital organs of albino mice in a gender specific manner. Albino mice, seven weeks old, were orally treated with 75 mg/ml solvent/Kg body weight of Lanthanum Zirconate nanoparticles for consecutive 22 days. Saline treated control groups were maintained in parallel. It was observed that rearing frequency was significantly decreased (P = 0.01) in NPs treated male mice. Complete blood count analysis indicated that NPs treated female mice had significantly reduced white blood cells (P = 0.05) and lymphocytes count (P = 0.03). NPs treated male had significantly reduced serum cholesterol levels (P = 0.05) than control group. It was observed that Superoxide dismutase concentrations in liver (P = 0.025) and kidney (P = 0.008), Malondialdehyde concentrations in liver (P = 0.044) of female and Malondialdehyde concentrations in kidney (P < 0.001) and brain (P < 0.001) and catalase concentrations in liver (P = 0.05) of NPs treated male mice were significantly higher than their respective control groups.. In conclusion, we are reporting that oral supplementation with 75 mg/ml solvent/Kg body weight of Lanthanum Zirconate nanoparticles can affect the behavior, leukocyte count, serum cholesterol and antioxidant metabolites from vital organs of albino mice in a gender specific manner.

Background: Acute appendicitis is most frequent cause of acute abdomen in younger population, and surgical site infection (SSI) is commonest complication of appendectomy. The objective of this trial was to compare the efficacy of post-operative oral antibiotics versus placebo in reducing the frequency of surgical site infection (SSI) following appendectomy for non-perforated appendicitis in population of South Waziristan Agency, Pakistan.Materials Methods: The randomized placebo trial was conducted at Agency Headquarter Hospital, Wana, South Waziristan, Pakistan from October 1, 2016 to November 18, 2018. One hundred fifty (150) patients were randomly allocated into two groups, 75 in experimental group, to whom antibiotics were given and 75 in placebo group, to whom antibiotics were not given. Age groups and presence of SSI were two variables, being on nominal scale, were described by count and percentage with CI at 80%CL. McNemar chi-square test was applied to test the hypothesis to see the significance of difference between the experimental and placebo groups in terms of frequency of SSI at alpha .05.Results: SSI was present in nine (12%, 80%CI 7.19-16.80%) out of 75 cases in experimental group and in 12 (16%, 80%CI 10.57-21.42%) out of 75 cases in placebo group. McNemar chi-square test showed no significant difference between the experimental and placebo groups in terms of frequency of SSI (p=.2482).Conclusion: The results are comparable for post-operative oral antibiotics versus placebo in reducing the frequency of surgical site infection (SSI) following appendectomy for non-perforated appendicitis in population of South Waziristan Agency, Pakistan.

Air pollution is among the nastiest form of pollutions causing vexation over the globe. The recent situation of eco-toxicity showed that whole planet is facing this misery explicitly or implicitly. The essence of this enigma is rapid urbanization and industrialization. Global developmental activities, deforestation, uncontrolled industrial emission and increase in vehicular load made this environment unfit for healthy life. This research work explored the effect of air pollution on Physiochemical attributes of Ficus religiosa L. planted along the polluted roadsides of Lahore city. Leaf area, ascorbic acid contents (AAC), total chlorophyll content (TCh), pH of leaf extract, relative water contents (RWC), and dust accumulation on leaves surface were measured using standard methods. Air Pollution Tolerance Index was computed, and the results were compared with the control plants from Changa Manga forest, 70 Km away from Lahore city in cleaner locality. Several Physiochemical alterations in F. religiosa growing in polluted arias were observed, including average leaf area (1367�14.25mm2), AAC (0.68� 0.021 mg/g), TCh (8.50� 0.017) pH of leaf extract (7.17�0.018), RWC (92.5�0.076 %), and dust accumulation on leaves surface (0.0716�0.00063 mg/cm2) compare to control. The recorded average APTI value (10.32�0.023) was higher in the plants grown along the polluted roads compared to controls (9.39�0.012). It is concluded from the results that air pollution tolerance level of F. religiosa was higher along the polluted roads of Lahore. It depicts that they are considerably affected the prevailing air pollution.

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