Highlights
SARS-CoV-2 expresses viral S-protein that exploits ACE2 to gain host cell entry.
The renin-angiotensin-aldosterone system influences SARS-CoV-2 pathogenicity.
ACE2-mediated endothelial infection partially explains vascular pathologies in COVID-19.
NSAIDs enhance viral replication and shedding in several known viruses.
Corticosteroids mediate pathways that may aggravate early infection.
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