In pursuit of the thus far illusive polycyclic arene episulfides (PAE)as model compounds for further study in relation to chemistry-based cancer researchwe have attempted the synthesis of phenanthrene episulfide by using phenanthrene oxide, phenanthrene, and 5,7-dihydrodibenzo[c,e]thiepin as key starting materials. Following preliminaty theoretical calculations of the targeted PAE's, the synthesis of 9,10-episulfide-trans-7,8-dihydroxy-7,8-dihydro[a]pyre.ne has been initiated. Our results indicate that apparently the elusive phenanthrene episulfide has been formed through the use of selected sulfur transfer agents, but the conditions to avoid its desulfurization should be worked out.
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