Diabetes is one of the most important medical and social problems in the world. Widespread, severity and variety of complications, the need for constant monitoring of laboratory parameters and dependence on regular medication are among the specific characteristics of the disease [1, p. 739; 2]. A significant proportion of patients are people from 20 to 60 years, mainly from low and middle income countries [3, p. 17; 4, p. 113].None of the many proposed methods and techniques for the treatment of chronic wounds satisfies practical surgeons completely due to a recurrence rate has also become high [2; 4, p. 114; 5, p. 34; 6, p. 63].The problem of blood circulation compensation is not solved only by drugs. In this regard, it is advisable to use a comprehensive treatment using modern rehabilitation methods, which include ozone therapy [6, p. 64; 7, p. 2452; 8, p. 99]. Due to the use of different routes of ozonized oxygen mixture can significantly improve homeostasis and rheological properties of blood, the body's immune response, to overcome local oxidative stress. As a
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