A new series of Zn II metal complexes of ligands 4-(4chlorobenzoyl)-5-methyl-2-phenyl-2,4-dihydro-3H-pyrazol-3one (PCBPMP) and 4-(4-chlorobenzoyl)-5-methyl-2-(p-tolyl)-2,4dihydro-3H-pyrazol-3-one (PCBTPMP) were prepared and characterized. The nature of bonding and the stereochemistry of the complexes were deduced from 1 H and 13 C Nuclear Magnetic Resonance (NMR), Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TGA), Molar conductivity measurements and Single-crystal X-ray diffraction. The analyses indicated that complexes 1, 2 and 3 are mononuclear and exhibited octahedral geometry around Zn II . The potential in silico and in vitro antimalarial activity inhibits Plasmodium falciparum and the same was exhibited by Ligands and Zinc complexes. This would be the first report of the antimalarial activity of Zinc complexes of acyl pyrazolones ligand.[a] I.
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