Lipoma are the most frequent mesenchymal soft tissue tumours but rarely present huge sizes in their cutaneous localization. Some cases of so-called "giant lipomas" have been reported in the literature and here is presented a giant lipoma of the axillary area which is, to our best knowledge, the second report of such a giant lipoma in this localization.
1 The e ect of the 5-hydroxytryptamine (5-HT) and noradrenaline (NA) reuptake inhibitor sibutramine was studied in food deprived, neuropeptide Y (NPY)-or muscimol-injected rats. 2 Sibutramine dose-dependently reduced feeding caused by food-deprivation (ED 50 =5.1+0.8 mg kg 71 ) or by NPY injection into the paraventricular nucleus of the hypothalamus (ED 50 =6.0+0.5 mg kg 71 ). The increase in food intake caused by muscimol injected into the dorsal raphe was not modi®ed by sibutramine (1 ± 10 mg kg 71 ). 3 The hypophagic e ect of 5.1 mg kg 71 sibutramine in food-deprived rats was studied in rats pretreated with di erent serotonin receptor antagonists. Metergoline (non-selective, 0.3 and 1.0 mg kg 71 ), ritanserin (5-HT 2A/2C , 0.5 and 1.0 mg kg 71 ) and GR127935 (5-HT 1B/1D , 0.5 and 1.0 mg kg 71 ) did not modify the hypophagic e ect of sibutramine, while SB206553 (5-HT 2B/2C , 5 and 10 mg kg 71 ) slightly but signi®cantly reduced it (Fint(2.53)=3.4; P50.05). 4 The reduction in food intake caused by 6.0 mg kg 71 sibutramine in NPY-injected rats was not modi®ed by GR127935 (1.0 mg kg 71 ). 5 The results suggest that, with the possible exception of a partial involvement of 5-HT 2B/2C receptors in sibutramine's hypophagia in food-deprived rats, 5-HT 1 and 5-HT 2 receptor subtypes do not play an important role in the hypophagic e ect of sibutramine, at least in the ®rst 2 h after injection.
Baseline [(18)F]FPRGD2 uptake was correlated with the pathological response in patients with LARC treated with CRT. However, the specificity was too low to consider its clinical routine use.
This is the first oncoplastic study where both tumor and breast characteristics were analyzed using the most recent criteria of the literature. Oncoplastic surgery can be considered as oncologically safe. The resection size was the sole significant risk factor for postoperative complications. Complications after oncoplastic breast surgery did not differ neoadjuvant therapy. Long-term event-free survival was excellent (96% at 7 years).
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