Hyperthermic intraperitoneal chemotherapy (HIPEC) is a procedure to delivered chemotherapy directly while heating in the peritoneal cavity after a special surgical effort which described as cytoreductive surgery (CRS). The aim of this method is to eliminate surgically and medically all the visible tumor deposits from different tumors. The last decade the interest of this treatment in peritoneal metastasis of different gynecological tumors as ovarian, endometrial or cervical are reported with different trials. This article reviews the current literature and evidence of this procedure.
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