Giant condyloma acuminatum (GCA) usually occurs on a set of human papillomavirus (HPV) subtype 6 or 11 infections and is characterized by cauliflower-like aggressive growing mass over the anogenital region. Lesions are more often observed in immunocompromised patients since host immunity is one of the main risk factors of the disease. We report a case of a GCA in a sexually inactive renal transplant recipient. A 25-year-old patient who had renal transplantation four years prior and has been receiving immunosuppression therapy since presented with the rapid growth of a vulvar mass noticed. A wide surgical excision was performed and the patient had no recurrence at her follow-ups. Surgical excision is the definitive treatment in immunocompromised patients with the rapid growth of vulvar condylomas.
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