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Cyclam-based antibacterial molecules (CAMs) that display potent activity against both the planktonic and stationary phase of multidrug-resistant Gram-negative bacteria were rationally designed.

A well balanced amphiphilic poly(propyleneimine) dendrimer (APPI-G2) was synthesized and used as an effective template for the stabilization of gold nanoparticle (AuNPs). The APPI-G2 served as a stabilizing as well as reducing agent for AuNPs. The APPI-G2 stabilized AuNPs (APPI-G2-AuNPs) were characterized by UV-visible spectroscopy (UV-Vis) and transmission electron microscopy (TEM). The size of the AuNPs was in the range of 7 to 16 nm and their growth during the synthesis showed splitting of surface plasmon resonance band. Further, APPI-G2-AuNPs were also prepared by varying the APPI-G2 concentration keeping [Au 3+ ] constant and vice-versa to examine the stabilization efficiency of APPI-G2. The APPI-G2 stabilized more than 5 × 10 −6 M of AuNPs. The prepared catalysts were found to exhibit enhanced catalytic activity towards the reduction of nitrobenzene in aqueous medium and the reaction rate constant was estimated to be 26.31 × 10 −3 s −1 .

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