HFSD is characterized by hypofibrinogenemia and accumulation of abnormal fibrinogen within hepatocytes. In addition, hypofibrinogenemia is associated with hypobetalipoproteinemia in Aguadilla mutation.
The results suggest that renal transplant recipients genetically predisposed to low expression of the regulatory cytokine IL-10 are more susceptible to high grades of IF/TA scores, graft inflammation, and high influx of inflammatory cells into the graft interstitium.
We observed an association between contrast-enhanced MRI renal perfusion and chronic allograft nephropathy severity. Further studies are needed to confirm this preliminary finding and to evaluate the role of contrast-enhanced MRI renal perfusion as a screening test for allograft dysfunction and potential utility in patient management.
Objective/Hypothesis:
Several inflammatory and allergic disorders have been reported to correlate with interleukin‐16 (IL‐16). IL‐16 is a highly potent chemotactic and chemoattractant molecule for eosinophils. Nasal polyposis (NP) has an inflammatory basis, and eosinophilia is a common finding in polyp tissue. In this study, we aimed to determine serum IL‐16 levels in NP patients.
Study Design:
Prospective controlled study in a tertiary academic hospital.
Methods:
Peripheral blood samples were obtained and used for serologic studies with enzyme‐linked immunosorbent assay kits to determine IL‐16 levels.
Results:
The study and the control groups consisted of 17 and 10 patients, respectively. Mean serum IL‐16 levels were significantly higher in the study group when compared to the control group (447.9 pg/mL vs. 260.2 pg/mL) (P < .001).
Conclusions:
Serum IL‐16 levels are significantly elevated in NP patients. This finding may represent identification of a valuable serum biomarker and potential therapeutic target in NP patients.
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