Summary. The efficacy of 1% ketoconazole shampoo in the treatment of dandruff was tested in a double‐blind, placebo‐controlled trial with 176 patients. The application of the shampoo twice weekly gave a good or excellent result in 74% of the patients treated with ketoconazole versus 20% of the patients treated with placebo after 2 weeks. After 4 weeks these results were 80% versus 23%.
The shampoo was well tolerated. Only one patient in the ketoconazole group stopped treatment because of greasy hair.
Zusammenfassung. Die Wirksamkeit eines 1%igen Ketoconazol‐Shampoos zur Behandlung von Kopfschuppen wurde in einer Placebokontrollierten Doppelblindstudie an 176 Patienten untersucht. Die wöchentlich zweimalige Anwendung des Shampoos ergab nach zwei Wochen gute bis ausgezeichnete Resultate an 74% der Ketoconazol‐behandelten gegenüber 20% der Placebo‐behandelten Patienten. Nach vier Wochen betrugen die Ergebnisse 80% gegenüber 23%. Der Shampoo wurde gut vertragen. Nur ein Patient in der Ketoconazol‐Gruppe gab die Behandlung wegen fettigen Haars auf.
The diagnosis of CFG has to be considered in patients with livedo reticularis, edema, painful purpura and slow healing ulcera after cold exposure. Cryofibrinogen-precipitates in the blood plasma have to be determined. Because secondary CFG occurs much more frequently than the primary form, it is important to rule out associated diseases through extensive physical examination and laboratory investigations. This communication also stresses the importance of a through family history of patients with CFG. An autosomal dominant mode of inheritance is supposed.
The diagnosis of CFG has to be considered in patients with livedo reticularis, edema, painful purpura and slow healing ulcera after cold exposure. Cryofibrinogen-precipitates in the blood plasma have to be determined. Because secondary CFG occurs much more frequently than the primary form, it is important to rule out associated diseases through extensive physical examination and laboratory investigations. This communication also stresses the importance of a through family history of patients with CFG. An autosomal dominant mode of inheritance is supposed.
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