Introduction: Recent evidence shows a possible causal relationship between periodontitis and neurodegenerative diseases. Changes in the hippocampus can result in reduced cognitive functions such as behaviors associated with memory and emotions. Objectives: Evaluate the influence of ligature-induced experimental periodontitis on the inflammation of the hippocampus of rats. Materials and Methods: Twenty male Wistar rats, divided into Control Group (GC) and Periodontal Disease Group (GDP). GDP was induced to experimental periodontitis by placing a ligature on the lower molars for 30 days. The study performed three behavioral tests during the experiment in two stages: before and after the induction of periodontitis; at the end, the rats underwent euthanasia and the collection of the hippocampus (histological and immunological analysis) and hemimandibles (histological and radiographic analysis), with subsequent performance of Student's T-tests and Two-Way ANOVA to analyze the results. Results: GDP showed a higher level of anxiety, less habituation and reduced time to explore the new object compared to GC (p<0.05). Besides, GDP had a lower number of osteocytes and osteoblasts, and higher osteoclastic activity, as well as more significant alveolar bone loss compared to GC (p<0.05). Senile plaques were noted in the hippocampus in addition to positive beta-amyloid, tau, and CD68 markings on GDP. Conclusions: Therefore, it can be concluded that periodontitis triggered the presence of senile plaques, beta-amyloid, tau, and CD68 markings, which, together, manifested an initial neuroinflammation process in these animals. Clinical Relevance: Periodontitis can be a risk factor in neuroinflammation process
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.