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The remarkable advances in biotechnology and health sciences have led to a significant production of data, such as high throughput genetic data and clinical information, generated from large Electronic Health Records (EHRs). To this end, application of machine learning and data mining methods in biosciences is presently, more than ever before, vital and indispensable in efforts to transform intelligently all available information into valuable knowledge. Diabetes mellitus (DM) is defined as a group of metabolic disorders exerting significant pressure on human health worldwide. Extensive research in all aspects of diabetes (diagnosis, etiopathophysiology, therapy, etc.) has led to the generation of huge amounts of data. The aim of the present study is to conduct a systematic review of the applications of machine learning, data mining techniques and tools in the field of diabetes research with respect to a) Prediction and Diagnosis, b) Diabetic Complications, c) Genetic Background and Environment, and e) Health Care and Management with the first category appearing to be the most popular. A wide range of machine learning algorithms were employed. In general, 85% of those used were characterized by supervised learning approaches and 15% by unsupervised ones, and more specifically, association rules. Support vector machines (SVM) arise as the most successful and widely used algorithm. Concerning the type of data, clinical datasets were mainly used. The title applications in the selected articles project the usefulness of extracting valuable knowledge leading to new hypotheses targeting deeper understanding and further investigation in DM.

Abstract. This paper proposes an ensemble method for multilabel classification. The RAndom k-labELsets (RAKEL) algorithm constructs each member of the ensemble by considering a small random subset of labels and learning a single-label classifier for the prediction of each element in the powerset of this subset. In this way, the proposed algorithm aims to take into account label correlations using single-label classifiers that are applied on subtasks with manageable number of labels and adequate number of examples per label. Experimental results on common multilabel domains involving protein, document and scene classification show that better performance can be achieved compared to popular multilabel classification approaches.

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This work studies the task of automatic emotion detection in music. Music may evoke more than one different emotion at the same time. Single-label classification and regression cannot model this multiplicity. Therefore, this work focuses on multi-label classification approaches, where a piece of music may simultaneously belong to more than one class. Seven algorithms are experimentally compared for this task. Furthermore, the predictive power of several audio features is evaluated using a new multi-label feature selection method. Experiments are conducted on a set of 593 songs with six clusters of emotions based on the Tellegen-Watson-Clark model of affect. Results show that multi-label modeling is successful and provide interesting insights into the predictive quality of the algorithms and features.

In many practical applications of supervised learning the task involves the prediction of multiple target variables from a common set of input variables. When the prediction targets are binary the task is called multi-label classification, while when the targets are continuous the task is called multi-target regression. In both tasks, target variables often exhibit statistical dependencies and exploiting them in order to improve predictive accuracy is a core challenge. A family of multi-label classification methods address this challenge by building a separate model for each target on an expanded input space where other targets are treated as additional input variables. Despite the success of these methods in the multi-label classification domain, their applicability and effectiveness in multi-target regression has not been studied until now. In this paper, we introduce two new methods for multi-target regression, called stacked single-target and ensemble of regressor chains, by adapting two popular multilabel classification methods of this family. Furthermore, we highlight an inherent problem of these methods-a discrepancy of the values of the additional input variables between training and prediction-and develop extensions that use out-of-sample estimates of the target variables during training in order to tackle this problem. The results of an extensive experimental evaluation carried out on a large and diverse collection of datasets show that, when the discrepancy is appropriately mitigated, the proposed methods attain consistent improve- Learn (2016) 104:55-98 ments over the independent regressions baseline. Moreover, two versions of Ensemble of Regression Chains perform significantly better than four state-of-the-art methods including regularization-based multi-task learning methods and a multi-objective random forest approach.

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