Iodine deficiency in childhood can influence the mental and somatic growth and development of children by decreasing the thyroid hormone production. Iodine deficiency can be quantified by testing ioduria concentration. Our study has analyzed ioduria concentration of children detected with stature delay, coming from two distinct regions of Sibiu County, namely Gura Rîului, a known endemic area, and Şeica Mare, a lowland region. Approximately 60% of these children with iodine deficiency were detected in both regions, but a much lower average of ioduria was identified in the endemic area, where 23% of children presented severe iodine deficiency. The results are related to those published in other articles and call for their extension to larger group of children throughout the country, because iodine deficiency is still an issue of public health with multiple effects on the mental and somatic growth and development of children.

The role of vitamin D in the human body is a complex one, proven by the many studies performed related to this aspect. Data from the literature on the correlation between vitamin D deficiency and thyroid autoimmune pathology, although present and increasing in the last 10 years, have failed to establish exactly whether or not there is a link between them. The aim of the study was to assess the status of vitamin D in patients with autoimmune thyroid disease; and to determine if there is a correlation between parameters such as: thyroid stimulating hormone (TSH), free thyroxine (FT4), ATPO; and vitamin D levels. Therefore, we performed a retrospective study in which we included 60 patients, 32 with autoimmune thyroid pathology and 28 patients with negative antithyroid antibodies. The average age of those in the case group was 58 years old and 52 years old for the control group. Female sex was predominant in both groups of patients, 97% in the study group and 71% in the control group. Vitamin D values ​​in patients with thyroid autoimmune pathology in our study were on average higher than those obtained in the control group (patients with negative thyroid antibodies), without finding a statistically significant difference between the values ​​of the two groups of patients (p = 0.197). The study shows a high prevalence of vitamin D deficiency in both groups of patients (with or without autoimmune thyroid disease), the highest rate being observed among patients without autoimmune pathology, but without a statistically significant difference between values.

The use of 3D models of the human bone system has great utility in the biomechanical study, due to the fact that these structures cannot be analyzed or tested in vivo. Within this paper, taking into consideration its real bone structure, the human femur CAD modelling is established. Firstly, a preliminary anatomical study is done, in order to highlight the fact that the thigh bone is a heterogeneous structure, consisting of several entities with different mechanical characteristics. The modelling starts from a homogenous 3D model of the femur, from which, every single separate entity is designed and finally they are assembled within a single product assembly. Therefore, the final result ensures a complex CAD structure, able to get assigned different material properties, specific for each entity this modelling furtherly allows the characteristic pathological structures studies of the referred entity or to simulate specific surgical interventions.

Orbital pseudotumor represents a benign inflammatory disorder of the orbit, with unspecified etiology, whose clinical presentation can mimic the ocular pathology of Basedow disease, namely Graves’ ophthalmopathy, the two of them representing two of the most common orbital conditions. Imagistic methods and laboratory analyses can establish the diagnosis through orbital MRI images specific for the orbital pseudotumor, especially by dosage of the TSH receptor antibodies (TRAb) which will have increased values in Basedow disease with ocular damage. In both situations, the treatment is represented as a first therapeutic line by administration of corticotherapy in high dosage orally or intravenously, with favorably evolution, which is also observable in the case of our patient who was diagnosed with orbital pseudotumor based on MRI images, with associated thyroid dysfunction with negative TRAb, in which the pulse therapy with Solumedrol has determined the improvement of ocular symptoms and signs.

Glucocorticoids are one of the most common classes of drugs used to treat a diverse variety of inflammatory and autoimmune disorders. Despite their effects, long-term therapy exposes patients to multiple side effects, such as weight gain, high blood pressure, adrenal insufficiency, osteoporosis and a high risk of infections. We present the case of a 61-year-old female with osteoporosis secondary to glucocorticoid therapy, adrenal insufficiency, new-onset diabetes mellitus and mixed dyslipidemia, manifestations that occurred as a result of self-administration of Medrol for one year. The patient presented to the hospital for thoracic back pain, being sent to the endocrinologist due to radiological changes suggestive of vertebral compressions.