Background: Recent studies have shown a positive correlation between Inflammatory markers and anorexia in CKD patients, which is a direct contributor to higher hospitalization rates, and higher death rates in hemodialysis patients. In addition, the impairment of renal function exhibits significant alterations in lipoprotein metabolism, which result in the development of severe dyslipidemia, that leads to the development of CVD. Objective: To evaluate the relationship between serum leptin with nutritional inflammatory and cardiovascular risk factors in non-diabetic ESRD Iraqi patients. Subjects & methods: Determination of serum leptin in 51 non-diabetic end stage renal disease patients and comparing it to the serum leptin in 47 healthy controls by ELISA. In addition, determination of serum hsCRP as a most important inflammatory factor, serum albumin and serum cholesterol as nutritional and atherosclerotic factor respectively. Results: serum leptin level is significantly higher in the patient group than the healthy control group (75.9± 23.7 vs 32.5±16.6). In addition, the serum leptin level is positively correlated with serum has CRP level (r = 0.45, p <0.01), serum cholesterol (r = 0.29, p <0.05) respectively. Conclusion: Leptin can be considered as a nutritional and inflammatory marker in non-diabetic ESRD Iraqi patients.
Objective: Neutrophil gelatinase-associated lipocalin has emerged as a promising biomarker of kidney injury better than creatinine to early predict the acute kidney injury in both chronic kidney diseases and early diagnosis of kidney allograft dysfunction. Methods:Neutrophil gelatinase-associated lipocalin was evaluated as a new biomarker for acute renal injury in 69 patients were divided in two groups chronic kidney disease patients (stage5), (n=34), and renal transplant patients, (n=35) comparing with apparently healthy control (n= 35) of matching age and weight. Neutrophil gelatinase-associated lipocalin, hsCRP and Cystatin-C were measured by enzyme-linked immune sorbent assay which is included first incubating the test serum in an antigen-coated polystyrene plate, then enzyme labelled anti-immunoglobulin is added and the enzyme then remaining in plate after washing provides a measure of the amount of specific antibody in the serum and in the final step a substance is added that the enzyme can convert to some detectable signal, most commonly a color change in a chemical substrate. Results:There was a significant increase in serum NGAL of renal transplantation patients, and CKD patients (stage5) than in healthy control subjects (455±145 ng/ml vs. 296.4±83.5 ng/ml 486±153 ng/ml vs296. 4±83.5 ng/ml) respectively. A high serum Neutrophil gelatinase-associated lipocalin is noted in renal transplanted patients after one month, then after six months (480±188ng/ml vs. 409±78ng/ml). There was a significant negative correlation between serum Neutrophil gelatinase-associated lipocalin in renal transplanted patients, and chronic kidney disease patients (stage 5) with an estimated glomerular filtration rate (p<0.05). Conclusion:Serum neutrophil gelatinase-associated lipocalin seems to be an early predictor of kidney injury and post-transplantation management, including dialysis and grafting function of the kidney.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.