Introduction: Perinatal HIV infection has decreased adverse bone health effects and mineral accrual. HIV-infected patients have a multifactorial origin, including HIV bone cell infections, inflammatory cytokine effects on osteoblast and osteoclast activity, and HAART. The research objective was to examine the correlation between the mandibular bone density and CD4 T-cells with HAART duration in HIV-infected children. Methods: The mandibular bone density in the HIV-infected pediatric population was evaluated using a panoramic radiograph. The research design was a cross-sectional and univariate regression analysis for the sampling method. Mandibular density analysis using Spearman and Pearson correlation and HAART duration using Kendall correlation. Thirty-five HIV-infected children and seventeen non-HIV-infected children were recruited. Results: This study showed the correlation between HIV and non-HIV infected children (p<0.05). The correlation between CD4 T-cells and mandibular bone density was significant (p<0.05). Long term HAART and mandibular bone density have a significant correlation (p<0.001). This research showed correlations between mandibular bone density CD4 T-cells and duration of HAART in HIV-infected children. Conclusion: HIV-infected children require a regular mandibular cortical bone examination to detect the onset of osteopenia and osteoporosis to obtain appropriate therapy.
Objective: To compare the effects of platelet-rich fibrin (PRF) and connective tissue graft (CTG) in gingival recession treatment using coronally advanced flap (CAF) Methods: Electronic Pubmed, Wiley, and EMBASE searches were conducted to identify articles published in dental journals without any restrictions of publication date. Gingival Recession Depth (RD), Keratinized Tissue Width (KTW), Probing Depth (PD), Clinical Attachment Level (CAL) and % Complete Root Coverage (CRC) were evaluated at baseline and 6 months. Patients with discomfort postsurgery was measured by comparing Visual Analog Scale (VAS) scores. Manual searches of human clinical trial and related articles were performed afterward. There are 31 studies explained about this, but only 6 studies met the inclusion criteria. Results:The initial database search produced 221 titles. All articles were selected for full-text review. Six studies were selected for inclusion, with 88 patients as subjects. Most of the studies showed the decreased of RD, PD, CAL and the increased of KTW in both techniques at baseline and 6 months follow up. The percentage of CRC showed higher in CTG rather than PRF whereas VAS score showed lower in PRF group Conclusion: Both PRF + CAF and CTG + CAF techniques are effective procedures in the treatment of gingival recession. The combination of CAF+CTG achieved a better result in root coverage however, PRF avoids a donor site, which means a major decrease in postoperative discomfort.
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