Diabetes is one of the top non-communicable illnesses of public health importance. 6.4% of world population is reported to have diabetes mellitus with the figure, feared to double by 2040. Nigeria has estimated 1.6 million cases in 2015, which ranked her the third diabetes endemic country in Africa. Diabetes complication is a known leading cause of the disease high mortality rates and healthcare burden on developing economies. Daily monitoring of blood sugar levels, however, is an effective way to prevent diabetes complications. Glucometer is a simple device used for blood glucose monitoring. The aim of this study was to design and use locally sourced materials to fabricate a cheap digital glucometer that will be able to measure blood glucose levels and sends a distress signal to medics and caregivers via wireless transmission.The method employed includes programming, calibration, assembling, component testing, and the overall device test. The device is equipped with an Atmega32 microcontroller, One-Touch Ultra glucose sensor, a GSM module, emergency button, and internet of things (IoT). Our device and a conventional device (Accuchek) were used to measure the blood sugar level of 200 individuals in groups of 5, the data were analyzed using SPSS2.0 and Microsoft Excel 2010.The p-value was (>0.05) indicating no significant difference between the data generated by our device and the conventional glucometer, while the coefficient of determination (R2) was 0.9838. From the results above, we conclude that our fabricatrd device is effective and reliable.
Many modern medicines are derived from the chemicals available in plants. The utilization of plants against diseases by traditional medical practitioners is common in many parts of the world and several researches have been carried out to determine the scientific basis for the use of such plants. Alstonia boonei is one of the many medicinal plants found in Nigeria. The plant parts have been traditionally used to treat various ailments including malaria. This study was carried out to evaluate the antimalarial activity, phytochemical composition and toxicity of ethanolic stem bark extract of Alstonia boonei. The extract showed substantial dose dependent antimalarial activity as indicated by the recorded suppressive (45.67%, 58.53% and 74.68% for 100, 200 and 400 mgkg-1 body weights) prophylactic (33.57%, 45.64% and 61.23% for 100, 200 and 400 mgkg-1 body weights) and curative effects (62.35%, 68.57% and 79.63% for 100, 200 and 400 mgkg-1 body weights) on Plasmodium berghei infected white albino mice. The results of the antimalarial tests were significantly different compared to the negative control at P < 0.05. The phytochemical evaluation showed that the plant contained important chemical compounds including tannins, flavonoids, steroids, phenols, alkaloids, saponins, glycosides and terpenoids. The acute toxicity test showed that the extract is safe as observed on the tested mice. It was concluded that the extract contains important active antimalarial compounds that are safe and should be further investigated for antimalarial drug development.
The increasing resistance of the malaria parasite to currently used antimalarial medicines has intensified the research for new novel antimalarial drug leads from natural sources. This study was carried out to evaluate the antiplasmodial potential, phytochemical composition and toxicity status of aqueous root extract of Alstoniaboonei (Apocynaceae), a medicinal plant used in treating malariain Nigeria and other African countries. The extract showed substantial dose dependent antiplasmodial activity as indicated by the, suppressive (40.18%, 55.72% and 61.55% for 100, 200 and 400 mgkg -1 body weights), prophylactic (51.39%, 65.27% and 68.35% for 100, 200 and 400 mgkg -1 body weights), and curative (48.63%, 59.59% and 60.88% for 100, 200 and 400 mgkg -1 body weights) effects on Plasmodium berghei infected albino mice. The antiplasmodial activity was significantly different compared to the negative control at P < 0.05.Chemical compounds obtained from the phytochemical evaluation of the extract include tannins, flavonoids, steroids, phenols, alkaloids, saponins, glycosides and terpenoids. There were no observed signs of toxicity in all the oral doses tested on albino mice. It was concluded that the extract contains important active antimalarial compounds that are not toxic and should be further investigated for antimalarial drug development.
This study, which is part of a project on the antimalarial potential of different extracts of Alstonia boonei plant parts, was carried out to determine the antimalarial property, chemical constituents and toxicity level of Alstonia boonei aqueous stem bark extract in white albino mice infected with Plasmodium berghei. The extract exhibited substantial dose dependent antimalarial property as shown by the suppressive effect (41.
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