(Hawkins and Phelps, 1988;Steen, 1992).Proton nuclear magnetic resonance imang (MRI) is well established as a diagnostic method in clnical oncology, but has been devoted less attention as a potential method for providing information on metabolic and physiological conditions in tumours (Steen, 1992;Rofstad et al., 1994). The proton spin-lattice and spin-spin relaxation times (T1 and T2, respectively) in tumours are influenced significantly by the fraction of free to bound water and the presence of paramagnetic ions (Braunschweiger et al., 1986;Negendank et al., 1991). The possibility has therefore been suggested that viable and necrotic regions in tumours might differ in T, and T2 (Banard et al., 1986;Belfi et al., 1991) and hence that MRI might be developed to be an efficient method for detection of necrotic regions in tumours (Dodd et al., 1989;DeJordy et al., 1992;Rofstad et al., 1994). Several in vitro studies of tumour cells and tissues have given results supporting this suggestion (Bakker and Vriend, 1983;Englund et al., 1986; Sillked et al., 1990
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