Introduction: The aim of this study is to compare molecule removal and albumin leakage in postdilution online hemodiafiltration with different high‐flux dialyzers.
Methods: We studied seven high‐flux dialyzers (Polyflux 210H®, Evodial 2.2®, FxCordiax1000®, Elisio21H®, TS‐2.1SL®, XevontaHi20®, VitaPES 210‐HF®) in 6 patients. The reduction ratio (RR) of small‐ and middle‐sized molecules was calculated. Dialysate samples were collected to estimate the albumin leakage.
Findings: Global differences between dialyzers were observed in the RR of ß2 microglobulin (P =0.003) and prolactin (P =0.013). The mean loss of albumin in the dialysate per session varied between 114 ± 67 mg (with Evodial 2.2) and 2621 ± 1363 mg per session (with XevontaHi20). We found global differences between dialyzers in total albumin loss (P = 0.05).
Discussion: We demonstrated that the performance of high‐flux dialyzers was different among the types and that not all high‐flux dialyzers should be considered equal.
Multidisciplinary approach with routine DU can improve VA results, with a decrease in primary failure rate, higher likelihood of radiocephalic AVF, better management of dis-functioning AVF and lower radiological test costs.
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