Background: Activation of the Stimulator of Interferon Genes (STING) pathway within immune and tumor cells of the tumor microenvironment (TME) results in durable anti-tumor effects via induction of innate and adaptive immunity. SB 11285 is a nextgeneration immunotherapeutic cyclic dinucleotide that activates the STING pathway leading to stimulation of tumor-resident APCs, NK cells and priming of tumor antigen specific CD8+ T cells. In preclinical studies using multiple tumor-derived cell lines, SB 11285 induced cytokines, such as IFN-a and -b, TNF-a and others consistent with
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