Purified gambir proved to have many pharmacological activities and has the potential to be developed into standardized herbal medicines. This study was conducted to determine the safety of purified gambir to liver histology. A total of 30 female white rats were used which divided into four groups: one control group and three test groups treated with purified gambir at doses of 5, 10, and 20 mg/kgbw orally for 14 days, respectively. On the scheduled days, three animals from each group were killed for liver histological examination. The degree of liver damage and liver organ ratio in this study where were measured. The reversibility of liver damage was observed from the change in the value of the damage degree, and liver organ ratio after the administration of gambir was stopped. Data were analyzed using twoway ANOVA followed by Duncan (significance was taken at p<0.05). The administration of purified gambir in rats for 14 days at tested groups caused significant liver tissue damage (p<0.05). In this situation, the degree of tissue damage increased, and the liver organ ratio decreased in all tested groups. After the administration was stopped, the liver damage degree decreased insignificantly, while the liver organ ratio is significantly increased.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.