[reaction: see text] Cobalt-mediated [2 + 2 + 2] cycloaddition of alpha,omega-diynes and isocyanates provides a direct approach to macrocyclic 2-oxopyridinophanes. This macrocyclization process, which proceeded most efficiently with aliphatic isocyanates, was conveniently performed at a moderate temperature (85 degrees C) without irradiation or syringe-pump addition.
Multi-membered O,N,S-heterocycles R 0692 Cobalt-Mediated Macrocyclizations. Facile Synthesis of 2-Oxo Pyridinophanes via [2 + 2 + 2] Cycloaddition of α,ω-Diynes and Isocyanates. -The cobalt-mediated [2 + 2 + 2] cycloaddition of the α,ω-diynes (I) with isocyanates can be performed at a moderate temperature (85°C) without irradiation or syringe-pump addition. The reaction proceeds most efficiently with aliphatic isocyanates. -(BONAGA, L. V. R.; ZHANG, H.-C.; GAUTHIER, D. A.; REDDY, I.; MARYANOFF*, B. E.; Org. Lett. 5
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