Background Restrictive mass quarantine or lockdown has been implemented as the most important controlling measure to fight against COVID-19. Many countries have enforced 2 -4 weeks' lockdown and are extending the period depending on their current disease scenario. Most probably the 14-day period of estimated communicability of COVID-19 prompted such decision. But the idea that, if the susceptible population drops below certain threshold, the infection would naturally die out in small communities after a fixed time (following the outbreak), unless the disease is reintroduced from outside, was proposed by Bartlett in 1957. This threshold was termed as Critical Community Size (CCS). Methods We propose an SEIR model that explains COVID-19 disease dynamics. Using our model, we have calculated country-specific expected time to extinction (TTE) and CCS that would essentially determine the ideal number of lockdown days required and size of quarantined population. Findings With the given country-wise rates of death, recovery and other parameters, we 1
As people age they almost invariably develop diseases which lead to the prescription of drugs – both to prevent disease progression and for symptomatic relief. Unfortunately, drug treatment in later life is also problematic. There is a dearth of evidence on the efficacy of drugs in people over the age of 80, and members of this age group are at highest risk of adverse drug reactions (ADR).
Informatics and technological advancements have triggered generation of huge volume of data with varied complexity in its management and analysis. Big Data analytics is the practice of revealing hidden aspects of such data and making inferences from it. Although storage, retrieval and management of Big Data seem possible through efficient algorithm and system development, concern about statistical consistency remains to be addressed in view of its specific characteristics. Since Big Data does not conform to standard analytics, we need proper modification of the existing statistical theory and tools. Here we propose, with illustrations, a general statistical framework and an algorithmic principle for Big Data analytics that ensure statistical accuracy of the conclusions. The proposed framework has the potential to push forward advancement of Big Data analytics in the right direction. The partition-repetition approach proposed here is broad enough to encompass all practical data analytic problems.
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