Key Points
Question
Is neurodegeneration associated with the early pathobiology of late-life depression?
Findings
This population-based cohort study of 4934 participants found that lower retinal nerve fiber layer thickness, an index of neurodegeneration, was significantly associated with higher incidence of clinically relevant depressive symptoms and more depressive symptoms over time, after adjustment for demographic, lifestyle, and cardiovascular risk factors.
Meaning
These findings suggest that neurodegeneration may be associated with the early pathobiology of late-life depression.
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