This work aimed at controlling the size of chitosan nanoparticles that were prepared by the ionotropic gelation method. Quantities of chitosan and sodium tripolyphosphate (STPP) were optimized to obtain a fine size and narrow size distribution of the nanoparticles. X-ray diffraction and selected area electron diffraction patterns indicated the existence of both crystalline and amorphous phases of chitosan. Particle size and size distribution were determined using transmission electron microscopy and dynamic laser scattering techniques. The size of the chitosan particles decreased with a reduction in STPP content due to a decrease in cross-link bonding and the formation of aggregate particles. Using this facile approach, the finest particles of chitosan were obtained in a range of 3-6 nm.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.