Objectives To evaluate the effect of a single-dose local administration versus the systemic administration of Erythropoietin on bone healing in calvarial bone defectsMaterial & Methods Critical-size cranial osteotomy defects were created in 30 rabbits. The animals were randomly divided into 3 groups. The animals were randomly divided into 3 groups (n= 10 animals in each group). In the Group I, the bone defect was only filled with a collagen sponge soaked with erythropoietin. In the Group II, it was filled with a collagen sponge and erythropoietin injected systemically. While in the Group III, the defect was filled with a collagen sponge. The groups were further split in two for euthanasia 10-and 21-days post-surgery. New bone formation and neovascularization were evaluated by hematoxylin-eosin. For the 10-days samples, all the groups analyzed for area percent of blood vessels while on the 21-day samples, the area of new bone formation was calculated. Differences between groups were analyzed by one-way ANOVA.Results At 10 days post-surgery, the histological analysis showed that the erythropoietin Groups exhibited a significantly higher percentage of bone formation compared with the other Group. At 21 days post-surgery, a higher percentage of new bone was observed in the erythropoietin group. ConclusionsThe results suggest that both local and systemic administration of erythropoietin hormone encouraged the bone healing in critical-size calvarial defects in Rabbits.
Objectives: the aim of the study was to evaluate the clinical and histological outcomes of extraction socket grafted with collagen cone in comparison to extraction site that healed naturally for implant site development. Patients & Methods: Twenty-six healthy patients require extraction of a single rooted tooth participated in this study. They had been divided into 2 groups. In Group I (control), the extraction socket was left with no graft to heal with secondary intention. While in group II (study), the socket was filled with collagen cone. Implants were inserted in average of 3 months after socket grafting. Cone Beam CT (CBCT) images were done prior to implant insertion to asses height and width of the ridge as well as bone density. Core biopsies were taken during implant placement. While implant stability test (ISQ) were done right after the implant was placed Result: The vertical bone changes at the grafted sockets were significantly lower (p < 0.0001) when compared to non-grafted sockets. Moreover, the width reduction of the grafted sites was significantly lower (p < 0.0001) than the non-grafted group. No significant difference was detected in RFA between two groups. Values of bone density was higher in the grafted sites. Conclusion: the alveolar preservation with collagen cone is an effective way to maintain the ridge dimensions after tooth extractions.
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