The prevalence of HIV in CSWs, drug users, and prisoners in Sindh is low at present. Intervention programs implemented at this stage can make an impact in HIV prevention.

Background: The prevalence of Diabetes is increasing globally and these numbers include women with Gestational diabetes mellitus also. Based on demographic projections made by United Nations Population Division for the year 2025, WHO issued estimates of adults with diabetes in all countries and reported that there will be more women with diabetes than men and we may anticipate a considerable increase in the burden of GDM especially in less prosperous countries. 'Gestational Diabetes Mellitus' (GDM) is defined as any degree of glucose intolerance with onset or first recognition during pregnancy. Worldwide prevalence of GDM varies between 1.4-14 %. The prevalence of Gestational diabetes mellitus in India varies from 3.8 to 21% in different parts of the country, depending on the geographical locations and diagnostic methods used. Gestational diabetes mellitus has been found to be more prevalent in urban areas than in rural areas.Women diagnosed to have GDM are at increased risk of future diabetes predominantly type 2 DM as are their children. Aims & Objective: To estimate the prevalence of Gestational Diabetes mellitus and various socio-demographic factors of the studied subjects. Material and Methods: A Community based cross sectional study was conducted in the field practice area of Government Medical College Srinagar (Block Hazratbal: District Srinagar).The study was conducted for a period of one year from April 2011 to March 2012. All pregnant women in 24 weeks of gestation and above after undergoing preliminary clinical examination were given a 75 g oral glucose load, without taking in to consideration the time since last meal. Gestational diabetes mellitus was diagnosed if 2 hour plasma glucose was ≥140 mg/dl (DIPSI guidelines, a modified version of the WHO criterion). Tests of proportions (Chi square) and unpaired t-test were used to obtain results. Results: A total of 306 women were registered for the study. The prevalence rate of gestational diabetes mellitus (GDM) was 7.8 % and all the cases were newly diagnosed during the study. Among various risk factors associated significantly with GDM were Gravida status, Parity and History of abortion. Overall, there was a preponderance of illiterate females (52.9%). However, the association between GDM and literacy was found to be non-significant at p > 0.05. The majority of females were home makers (96.4%) and occupation did not influence the prevalence of GDM. Majority of the studied population belonged to socioeconomic class III (Modified BG Prasad). Conclusion: Increasing prevalence of gestational diabetes mellitus and its co-morbidities among females need immediate attention in terms of prevention and health education.

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Objectives:To assess the epidemiological profile of asthma in school going children in Srinagar, Kashmir.Study design:Cross-sectional study.Setting:Thirty-one schools with proportionate representation from both government and private schools as well as from primary, middle, and high schools.Participants:School children aged 10–16 years with equal representation of sex and all ages.Main Outcome Measure:Prevalence of current and past asthma.Methods and Results:After administering a modified pretested questionnaire, peak expiratory flow measurement was carried. Children who had asthma-like symptoms or positive family history of asthma or physician-labeled asthma were subjected to spirometry and bronchodilator reversibility. Out of 806 children, bronchial asthma was seen in 60 (prevalence of 7.4%) which included 34 boys and 26 girls. Majority of asthmatic children (78.3% [n = 47]) had probable asthma; 6.7% (n = 4) had definite asthma; and 15% (n = 9) had physician-diagnosed asthma. Majority of children had intermittent asthma (78.3% [n = 47]). Mild persistent asthma was seen in 12.7% (n = 7) and 10% (n = 6) had moderate persistent asthma. None of the children had severe persistent asthma. The prevalence of current asthma was 3.2% (n = 26). On univariate analysis, the factors found to be statistically significant were family history of asthma (odds ratio [OR] =8.174; confidence interval [CI] =4.403–15.178), seasonal cough (OR = 4.266; CI = 2.336–7.791), allergic rhinitis (OR = 2.877; CI = 1.414–5.852), atopic dermatitis (OR = 6.597; CI = 2.72–16.004), and obesity (OR = 6.074; CI = 2.308–18.034). On multivariate analysis, family history, seasonal cough, allergic rhinitis, atopic dermatitis, and obesity were found to be significant independent risk factors.Conclusions:Srinagar qualifies as a low prevalence area for bronchial asthma in the age group of 10–16 years. Majority of children had mild intermittent asthma resulting in under diagnosis and wrong treatment.

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Background Alopecia in women is generally difficult to diagnose clinically. Trichoscopy may help make the correct diagnosis in doubtful cases. Objective The aims of the study were to assess the trichoscopic features of different types of alopecia in women, the reliability of trichoscopy vis-à-vis clinical findings, and the validity of trichoscopy in cases with a doubtful clinical diagnosis. Methods A hospital-based observational, cross-sectional study was carried out on female patients with alopecia. A trichoscopic diagnosis was made and correlated with a clinical diagnosis. The validity of trichoscopy in doubtful cases was evaluated by reporting the sensitivity, specificity, positive predictive value, negative predictive value, and diagnostic value. Results On trichoscopy, increased hair diameter diversity > 20%, single-hair follicular unit, vellus hair, peripilar sign, and focal atrichia were commonly seen in female pattern hair loss. In telogen effluvium, there was a scarceness of specific findings. In cicatricial alopecias, loss of follicular ostia, erythema, white macules, blue-gray dots, white dots, tufted hair, and keratotic follicular plugging were observed. A good agreement between trichoscopy and clinical diagnosis was found (Cohen’s Kappa = 0.824; 95% confidence interval, 0.756–0.892). The validity of trichoscopy in doubtful cases was evaluated using the validity parameters, which were high in all alopecias. Limitations Histopathology testing was not done in all patients. Conclusion Trichoscopy helped reach a definitive diagnosis in patients in whom the clinical diagnosis was doubtful. Thus, trichoscopy is a sensitive and specific investigation that can be valuable in women with alopecia.

Rosuvastatin is regularly recommended for the treatment of hypercholesterolemia and applies its impact through focused collection in the liver. Current dosing rules show no inclination for sustained or fasted rosuvastatin organization. In this investigation, lower plasma level was noted in mice with nourishment 2 hours after an oral rosuvastatin portion, while liver fixation was unaffected. We presume that taking an oral portion with nourishment rather than on an unfilled stomach, don't fundamentally influence the cholesterol-bringing down limit of rosuvastatin. Since a typical unfavorable occasion noted with statin treatment is muscle torment/harm related with high coursing statin levels, our discoveries can possibly fill in as a novel and basic system for relieving statin myopathy hazard.

Background and Aims: Foreign-body ingestion is a common phenomenon, especially in children. In normal adults, foreign-body ingestion is usually accidental and mostly ingestion occurs with food and impaction is a result of structural abnormalities of the upper gastrointestinal tract (UGIT). However, accidental ingestion of nonfood products is unusual; especially ingestion of pins (scarf or safety pins) and needles is unknown. We come across ingestion of these unusual/sharp foreign bodies routinely from the past few years. The aim of this study was to observe, over a period of 1 year, the spectrum of nonfood or true foreign-body ingestion in our community and to see the impact of an early endoscopy on outcome or retrieval of the ingested objects. Materials and Methods: In a prospective observational study, we studied the profile of foreign-body ingestion in normal individuals of all ages and both sexes, excluding the individuals with any structural abnormalities of the gut and the people with psychiatric ailment. Results: Of total 51 patients with foreign-body ingestion, 42 (82%) were 20 or <20 years of age with females constituting 86.3% of the total and males constituting only 13.7%. Foreign bodies ingested included 38 pins (74.5%), seven coins (13.7%), four needles (7.8%), and one denture and a nail (2%) each. Overall 26 (51%) foreign bodies were seen in UGIT (within reach of retrieval) at the time of endoscopy and all of them were retrieved. Nineteen (37.3%) patients reported within 6 h of ingestion, and majority of them (16 = 84.2%) had foreign bodies within UGIT and all of them were removed. Those patients (n = 32; 62.7%) who reported beyond 6 h, only 10 (31.25%) had foreign bodies in UGIT as a result of which the success rate of removal in these patients was only 32%. Conclusion: Most of our patients were young females and the common foreign bodies ingested were sharp including scarf pins followed by coins and needles. The success rate of retrieval was high in those who reported within 6 h of ingestion of foreign body. The rate of retrieval was 100% if foreign body was found on esophagogastroduodenoscopy. Hence, we recommend an early endoscopy in these patients and some alternative to use of scarf pins. AbstractThis is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.