Results 480 biomarker assays were performed in 80 samples from ten infants. OI correlated positively with BNP, NTproBNP, and VEGF-A, and negatively with PLGF (Table 1). PH measures correlated negatively with PLGF and positively with NTproBNP and Troponin1. Measures of diastolic function correlated negatively with Troponin1 and VEGF-A, and positively with PLGF. Conclusions 1) Plasma biomarker analysis is feasible in infants with PH in CDH. 2) Worsening disease status (impaired oxygenation, PH, diastolic dysfunction) was associated with elevated BNP, NTproBNP, Troponin1 and VEGF-A, and reduced PLGF. 3) The utility of these peptides as disease biomarkers, prognostic indicators, and their role in disease pathogenesis merits further investigation.
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