An estimated 300 million people worldwide suffer from chronic hepatitis C with a prevalence of 0.8%-1.0% of the general population in Canada. An increasing pool of evidence exists supporting the use of pegylated- interferon (pegIFN) and ribavirin combination therapy for hepatitis C. We report a 49-year old male of North American aboriginal descent with chronic hepatitis C (genotype 2b). Biopsy confirmed that he had cirrhosis with a 2-wk history of left eye pain and decreased visual acuity. He developed retinal vein thrombosis after 16 of 24 wk of pegIFN-alpha 2a and ribavirin combination therapy. He was urgently referred to a retinal specialist and diagnosed with non-ischemic central retinal vein occlusion of the left eye. PegIFN and ribavirin combination therapy was discontinued and HCV RNA was undetectable after 16 wk of treatment. Hematologic investigations revealed that the patient was a factor V Leiden heterozygote with mildly decreased protein C activity. Our patient had a number of hypercoagulable risk factors, including factor V Leiden heterozygosity, cirrhosis, and hepatitis C that alone would have most likely remained clinically silent. We speculate that in the setting of pegIFN treatment, these risk factors may coalesce and cause the retinal vein thrombosis.
Paduan zirkonium banyak digunakan pada reaktor nuklir karena keunggulan dan sifat mekaniknya serta tahan korosi dalam air pada temperatur tinggi. Salah satu usaha untuk lebih meningkatkan sifat mekanik paduan zirkonium adalah dengan melakukan proses perlakuan panas β-quenching. Dalam penelitian ini telah dilakukan proses perlakuan panas pada logam paduan zirkonium hasil peleburan dengan menggunakan tungku pelelehan busur tunggal (Single Arc Melting Furnace). Proses perlakuan panas dilakukan dengan cara memanaskan paduan zirkonium (Zr-AI) sampai temperatur pemanasan 900oC dengan waktu penahanan 60 menit, kemudian di celup cepat (quenching) dengan menggunakan media air. Hasil analisis dengan menggunakan mikroskop optik menunjukkan bahwa ingot hasil peleburan mempunyai struktur dendrit dan parallel plate dengan Struktur mikro hasil perlakuan panas adalah dendrit. Untuk mengetahui nilai kekerasan paduan Zr-Al dilakukan uji kekerasan mikro vickers. Harga kekerasan hasil perlakuan panas untuk semua paduan berkisar antara 799.33 Hv sampai 890 Hv.
Problem statement:The aim of feature selection is to select a feature set that is relevant for a given application. Feature selection is complex and remains an important issue in many domains. In the field of neural networks, feature selection has been used in many applications and their methods have been employed. In this study we present neural network approaches to feature selection. Approach: In this study a reduction algorithm of the features vector dimension was described by eliminating its selected components on the basis of analyzing the results of teaching a neuron, which has a linear activation function of the type. In the presented algorithm, the value of the mean square error, which appears after the reduction, is the criterion, on the basis of which the components of the eliminated vector were selected. The algorithm is based on the analysis of the classifier of balances vector. Results: The results of calculations obtained when analyzing the data describing an example-task of medical diagnosis were presented as an illustration. Results from the experiment indicate that the elimination of components of features vector using the Reduction algorithm did not cause the increase of the value of mean square. Conclusion: Our study showed that, results provide experimental evidences on the effectiveness of the proposed approach for feature selection in the bioinformatics applications.
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