For the very first time, highly efficient synthesis of DNA-peptide hybrids to scaffold self-assembled nanostructures is described. Oligonucleotide conjugation to the diphenylalanine dipeptide triggers a morphological transition from fibrillar to vesicular structures which may potentially be used as delivery vehicles, since they exhibit pH triggered release.
With this review, we aim at achieving a comprehensive and up to date look at the broad topic of DNA conjugates as well as summarizing the important trends in the particular field of materials based on nucleic acids
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