пятигорский медико-фармацевтический институт -филиал Волгоградского государственного медицинского университета, Российская ФедерацияThe carDioproTecTiVe effecT of 3-formYlchromone DeriVaTiVes. focus on changes in The funcTional acTiViTY of miTochonDria pozdnyakov D. i., rybalko i. e., sarkisyan K. h. pyatigorsk medical and pharmaceutical institute -branch of the Volgograd state medical university, russian federationПроведено изучение кардиопротекторной активности шести новых производных 3-формилхромона в сравнении с триметазидином и мельдонием при курсовом терапевтическом пероральном введении в условиях экспериментального инфаркта миокарда. Установлено, что применение производных 3-формилхромона увеличивает активность цитратсинтазы и соответственно метаболическую активность интерфибриллярных митохондрий, подавляя при этом образование супероксид-радикала в субсарколеммальных митохондриях, уменьшая зону некроза миокарда. Ключевые слова: инфаркт миокарда, производные 3-формилхромона, митохондриальная дисфункция, кардиопротекцияA study evaluated the cardioprotective activity of six new derivatives of 3-formylchromone in comparison with trimetazidine and meldonium during the course of therapeutic oral administration in experimental myocardial infarction. As a result, it was found that the use of 3-formylchromone derivatives increases the activity of citrate synthase and, accordingly, the metabolic activity of interfibrillary mitochondria, while suppressing the formation of a superoxide radical in subsarcolemal mitochondria, reducing the zone of myocardial necrosis.

Introduction. Chronic venous diseases are a common group of diseases with a significant risk of complications requiring timely correction. As a rule, phlebotonic drugs based on flavonoid complexes are used for the treatment and prevention of venous diseases.Aim. To evaluate the effectiveness of the use of various phlebotonic drugs in the conditions of experimental chronic venous insufficiency.Materials and methods. Varicose veins were modeled in Wistar rats by partial stricture of the deep femoral vein. The studied medicines were administered orally in a course of 30 days from the moment of surgery. During the work, the change in the following parameters was evaluated: the rate oflocal blood flow in the skin in dynamics, the degree of vascular permeability, the concentration of proinflammatory cytokines (TNF-α, IL-6) and matrix metalloproteinase 9 (MMP9) in the vascular wall. The rate of local blood flow was assessed by ultrasound Dopplerography. The change of vascular permeability was studied by the degree of extravasation of the Evans blue dye in the Miles test. The content of proinflammatory cytokines and MMR9 was determined by enzyme-linked immunoassay. The results were statistically processed.Results. The study showed that the course oral administration of all the studied venotonizing drugs led to the restoration of hemodynamics and a significant (p˂ 0.05) decrease in the degree of vascular permeability in relation to untreated animals. It is worth noting that the use of a micronised purified flavonoid fraction 1 contributed to the development of a more pronounced vasal effect, which was reflected in an increase in blood flow velocity and a decrease in vascular permeability compared to the rest of the studied drugs. At the same time, the administration of micronised purified flavonoid fraction 1 to animals led to a statistically significant decrease in the concentration of proinflammatory cytokines, which was not observed when using other drugs.Conclusion. The course administration of the micronised purified flavonoid fraction 1leads to the development of a pronounced phlebotonic effect, expressed in the restoration of microcirculation, a decrease of the inflammation in the vascular wall.