Objectives: Resveratrol (RSV) is a natural polyphenolic compound showing significant antioxidant effects. In this study, we aimed to investigate the effects of resveratrol on the sphingosine-1-phosphate (S1P) and oxidative stress biomarkers in hearth ischemia-reperfusion (I/R).
Materials and Methods: The biochemical and histopathological effects of RSV on cardiac ischemia-reperfusion injury were investigated through ELISA- and light microscope.
Results: We observed statistically significant differences between the treatment group and the control group in terms of malondialdehyde (MDA) level, catalase (CAT) and superoxide dismutase (SOD) activities (p<0.05). Histopathologically, we also observed decreased Polymorphonuclear Leucocyte (PMNL) infiltration, myocardial edema, miyositolysis in the treatment group compared to the I/R and sham groups.
Conclusion: Resveratrol may play an important role in cardiac I/R injury through its anti-inflammatory and antioxidant effects which were biochemically and histopathologically confirmed in the present study.
Menengiç (Pistacia terebinthus L.), Işgın (Rheum ribes L.) ve Çiriş Otu (Asphodelus aestivus) tüm dünyada yaygın olarak bulunur ve genellikle taze olarak tüketilir. Bu çalışmada, gövde ve yaprakları seçilen üç bitkinin antioksidan aktivitelerinin incelenmesi amaçlandı. Menengiç, ışgın ve çiriş otu Kahramanmaraş bölgesinde farklı marketlerden alındı. Seçilen bitkilerin gövde ve yapraklarında antioksidan enzimler olarak superoksit dismutaz (SOD) ve katalaz (CAT) aktiviteleri ile oksidatif stresin göstergesi olarak olarak malondialdehit (MDA) düzeyi spektrofotometrik olarak ölçüldü. Menengiç, ışgın ve çiriş otu 'nun SOD ve CAT aktiviteleri karşılaştırıldığında; en yüksek CAT aktivitesi ışgın’da ölçülürken, çiriş otu’nda ise en düşük bulundu (p
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