We present a case of severe microangiopathic hemolytic anemia and thrombocytopenia with epistaxis, gross hematuria, hemoglobinuria, and skin purpura in a child with Brucella septicemia proven by culture. The patient showed the features of this illness: leukopenia, severe hemolytic anemia, thrombocytopenia, fragmentation of erythrocytes in the peripheral blood smear, increased erythropoiesis, megakaryopoiesis, and granulomata cell invasion in the bone marrow. The patient was treated with rifampin and doxycycline. Platelets and leukocyte numbers rose to normal values by the 6th day. She was discharged on the 14th day. Follow-up of the patient 1 year later showed normal bone marrow morphology. Differential diagnosis, pathogenesis, and therapy of Brucella infection are discussed.
Summary:The aim of this study was to study the usefulness of erythrocyte antigen (EA) measurement to study engraftment after allogeneic HSCT. In all, 31 consecutive patients receiving HLA-identical bone marrow (BM) (n ¼ 13) or peripheral blood stem cells (n ¼ 18) were investigated. Apart from the ABO group, 15 EAs representing six minor blood groups were followed by the simple tube agglutination technique. A total of 20 (64.5%) patients received ABOidentical, eight (25.8%) received ABO minor and three (9.7%) received ABO major mismatched grafts. In all, 29 patients were followed for a median of 12 (6-16) months; 65% of the patients expressed donor type EA 1 month and almost all did so 6 months after transplant. Reticulocyte engraftment was significantly shorter than EA engraftment (median 18 vs 35 days) (P ¼ 0.001). Patients who received PB stem cells showed significantly faster EA and reticulocyte engraftment than patients who received BM stem cells (P ¼ 0.038 and 0.025). ABO compatibility did not have an impact on reticulocyte and EA engraftment (P ¼ 0.4 and 0.55). The earliest donor type EA detected was from the Rh and Kidd system. These data suggest that EA and reticulocyte assays are useful in monitoring engraftment. 4 Flow cytometric analysis using monoclonal antibodies directed against blood group antigens enabled sensitive evaluation of dual RBC populations. 5 Our aim was to study a simple tube hemagglutination method for monitoring RBC repopulation following HSCT. In addition, we evaluated the disappearance of recipient-derived RBC antigens and appearance of donorderived antigens after transplantation, and correlated RBC antigen engraftment with reticulocyte counts after AHSCT. Patients and methods PatientsA total of 31 consecutive HSCT patients were studied. They consisted of 11 females and 20 males with a median age of 36 years (range 18-51). The underlying diseases were chronic myeloid leukemia in 18, acute leukemia in 11, severe aplastic anemia in one and renal cell carcinoma in one patient. In all, 13 of the patients received bone marrow (BM) and 18 received peripheral blood stem cells (PBSC) from their HLA-identical siblings. Eight of the patients received minor and three received major ABO-incompatible grafts. Table 1 shows the patient and donor characteristics. Transplantation procedureThe patients were conditioned by ablative cyclophosphamidebased regimens (81%) or fludarabine-based reduced intensity regimens. 6 All the patients received short-course methotrexate and cyclosporine for GVHD prophylaxis. All the donorrecipient pairs were CMV-seropositive. Recombinant human G-CSF was used until neutrophil engraftment after day þ 1 in BM group, but not in the PBSC. All the blood products were leucofiltered and irradiated. The pretransplant evaluation of the mismatched patient-donor pairs, the decision for erythrocyte and plasma depletion of the harvest and posttransplant transfusion policy were designed by our transplant center's transfusion medicine consultant (Dr Arslan), according to recently pu...
Profesyonel anlamda halkla ilişkiler uygulamalarının tarihi 1900'lü yıllardan başlamakta ve genellikle Amerika Birleşik Devletleri'ndeki öncüller aracılığıyla aktarılmaktadır. Ivy Lee ve Edward L. Bernays üzerinden aktarılan bu tarih anlatısında kadın öncüllerin göz ardı edilmesi çalışmanın motivasyon noktasını oluşturmaktadır. Çalışmanın temel amacı halkla ilişkiler alanın kuruluşunda ve gelişiminde önemli işler yapmış olan ve Türkiye'deki halkla ilişkiler literatüründe yer almayan Doris Elsa Fleischman'ın alana katkılarını görünür kılmaktır. Bu bağlamda öncelikle Türkiye'de yayınlanmış halkla ilişkiler kitapları incelenerek literatür taraması yapılmış, sonrasında Amerika Birleşik Devletleri halkla ilişkiler tarihinde önemli bir yeri bulunan Fleischman'ın halkla ilişkiler alanına katkıları olumsuz örnek olay yöntemiyle analiz edilmiştir. Sonuç olarak Bernays'ın şirketinin eş ortağı olan Doris E. Fleischman'ın, alanın adlandırılmasından uygulamalardaki katkılarına kadar pek çok alanda faaliyette bulunduğu ve akademik yayınlar yaptığı tespit edilmiştir.
Research ArticleThe study aims to assess the social perspective on transition to the normalization process as many COVID-19 restrictions are easing as of June 1, 2020 in Turkey. As a global crisis, COVID-19 requires a correct and effective risk communication and management in all processes. During a pandemic, social reflections cannot be ignored. Analyzing the opinions that the society has experienced and agreed upon will be a guide for future risk communication studies. In accordance with this purpose, the literature on the COVID-19 pandemic was reviewed, and 24 original questions were prepared. Field study was conducted online between 22-25 June 2020. The population has been determined as Ankara, which is Turkey's second most populated city. 1230 people participated in the study. The findings showed that the participants thought that the decreasing number of cases and deaths caused complacency; they trusted their environment more than others, and the decision of transition to the normalization did not reduce the anxiety level of the society. It is concluded that the participants preferred to stay away from activities which could be risky for their own health and were hesitant to go to healthcare organizations for medical tests and treatments that they postponed. It is observed that the participants believed that normalization was initiated early, and this decision was made due to economic concerns. As a result, it must be stated that, in order to manage the risk correctly, the society's need for information should be satisfied with accurate and clear information, individual measures should be maintained, public and health authorities should take the necessary measures, and all of these necessities should be supported by the media.
One of the diseases that historically experienced stigma and exclusion is obesity. Today, as in many areas of life such as education, business life, health services and social life, discriminatory stigmatizing approaches are encountered in the media about obesity. This study aims to reveal the views and expectations of individuals with obesity in Turkey about the issues they are discriminated against in the media, the forms of stigmatization, and the representations of obesity in the media. In the study, focus group interview method, one of the qualitative research methods, was used. 6 different focus group interviews were conducted: 15-24, 25-49, 50 years and older low income-high income. A total of 42 people, 22 women and 20 men, participated in the interviews. All of the participants have criticisms about the representation of obesity in the media. They stated that in the media contents, obesity should not be presented as a problem of willpower but as a disease, that accurate information about this disease should be included, and that beauty and aesthetic concerns should not take precedence over the causes and consequences of the disease. They believe that the media has a great role in this regard. As a result, stereotypes and stigmatizing discourses in the media imprison individuals with obesity within certain limits. Individuals with obesity define themselves as people who are labeled and stigmatized. In short, media content reinforces discrimination. It must be underlined that the contents/presentations that are used in order to raise awareness in the media reproduce discrimination. It is clear that improvement and correction in media content must occur quickly. There is a need for programs/series/movies that are free from deceptive and misleading information, that are far from a biased perspective towards individuals with obesity, and where obesity is framed with accurate information. Due to the power of the media in influencing and directing society, recognizing and changing such content in the media will make a great contribution to the understanding of the problems experienced by people living with obesity, and therefore, contribute to obesity treatments.
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