Aim: Obesity, insulin resistance, and hyperlipidemia have been shown as risk factors for non-alcoholic fatty liver disease. In this study, the association between lipid and lipoprotein metabolism abnormalities and the presence of non-alcoholic fatty liver disease was investigated in patients with obesity. Material and Methods: In this study, the clinical, laboratory and imaging findings of 357 children and adolescent patients (199 girls and 158 boys) aged 2–18 years who were diagnosed as having obesity between 2013 and 2018 were retrospectively analyzed. The clinical and laboratory features of the patients who were diagnosed as having non-alcoholic fatty liver disease using ultrasonography were compared with patients who did not have non-alcoholic fatty liver disease. All lipid and lipoprotein levels were defined as hypo-, normo- and hyperlipidemic in comparison with the reference values according to age and sex. Results: The frequency of non-alcoholic fatty liver disease was 44.5% in the entire study group and was higher in males (p<0.05). The body weight, body mass index, alanine aminotransferase, glucose, insulin, non-high-density lipoprotein-cholesterol, and HOMA-IR scores were found to be higher in the patients with non-alcoholic fatty liver disease, whereas the high-density lipoprotein-cholesterol level was lower (p<0.05). There was no difference in the frequency of non-alcoholic fatty liver disease among the patients with low, normal, and high total cholesterol, triglyceride and low-density lipoprotein-cholesterol levels (p>0.05). The frequency of lipid metabolism disorder (hypolipidemia and/or hyperlipidemia) was found as 77.5% in all patients. Conclusion: Non-alcoholic liver disease and lipid metabolism disorders are common in children and adolescents with obesity. The frequency of non-alcoholic fatty liver disease in hypolipidemic, normolipidemic, and hyperlipidemic patients was not different. This finding indicated that the increase in the amount of body fatty tissue and insulin resistance were more important risk factors in the development of non-alcoholic fatty liver disease.
üt çocukluğu ve çocukluk döneminde görülen ketotik hipoglisemilerin nadir bir nedeni glikojen depo Tip 0 hastalığı [glycogen-storage disease Type 0 (GSD-0)]'dır. Bu hastalığa karaciğer glikojen sentetaz (GS) eksikliği neden olmaktadır. 1 İlk kez 1963 yılında Lewis ve ark. mental retardasyon ve hipoglisemik atakları olan bir hastanın karaciğer biyopsisinde GS aktivitesini sıfır olarak saptayarak bu hastalığı tanımlamışlardır. 2 Şimdiye kadar 30 GSD-0 hastası tanımlanmıştır. 3 GS eksikliğinde karaciğerde glikojen depoları belirgin azalmaktadır. Bu nedenle GSD-0 hastalığı, glikojen depo hastalıkları içinde sınıflanmasına
Abstracts ADC 2019;104(Suppl 3):A1-A428 A365
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