Within the last decade, there has been increasing interest in liquid and solid foams for several industrial uses. In the biomedical field, liquid foams can be used as delivery systems for dermatological treatments, for example, whereas solid foams are frequently used as scaffolds for tissue engineering and drug screening. Most of the foam functionalities are largely correlated to their mechanical properties and their structure, especially bubble/pore size, shape, and interconnectivity. However, the majority of conventional foaming fabrication techniques lack pore size control which can induce important inhomogeneities in the foams and subsequently decrease their performance. In this perspective, new advanced technologies have been introduced, such as microfluidics, which offers a highly controlled production, allowing for design customization of both liquid foams and solid foams obtained through liquid-templating. This short review explores both the fabrication and the characterization of foams, with a focus on solid polymer foams, and sheds the light on how microfluidics can overcome some existing limitations, playing a crucial role in their production for biomedical applications, especially as scaffolds in tissue engineering.
Solid foams with micrometric pores are used in different fields (filtering, 3D cell culture, etc.), but today, controlling their foam geometry at the pore level, their internal structure, and the monodispersity, along with their mechanical properties, is still a challenge. Existing attempts to create such foams suffer either from slow speed or size limitations (above 80 μm). In this work, by using a temperature-regulated microfluidic process, 3D solid foams with highly monodisperse open pores (PDI lower than 5%), with sizes ranging from 5 to 400 μm and stiffnesses spanning 2 orders of magnitude, are created for the first time. These features open the way for exciting applications, in cell culture, filtering, optics, etc. Here, the focus is set on photonics. Numerically, these foams are shown to open a 3D complete photonic bandgap, with a critical index of 2.80, thus compatible with the use of rutile TiO2. In the field of photonics, such structures represent the first physically realizable self-assembled FCC (face-centered cubic) structure that possesses this functionality.
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