Cytological changes in the thyroid glands of 120 patients who had received 131I treatment for hyperthyroidism were examined in detail. The cytological material was obtained by fine needle aspiration cytology. The patients were divided into four groups according to the amount of time elapsed after the 131I treatment. The control groups were selected from euthyroid patients with hypoactive or non-functional solitary nodules and patients with Graves' disease who had not received 131I therapy. The thyrocytes revealed degenerative changes in the immediate period after cessation of treatment. One year after the treatment some non-specific changes, such as oxyphilic metaplasia and regeneration, were seen. No malignant change has been observed clinically or cytologically during up to 20 years of follow up since receiving 131I.
anaemia, transient abnormal myelopoiesis, post-transplant lymphoproliferative disorder and Fanconi anaemia. Of the remaining 154 patients diagnosed with cancer, 88 (57.1%) were classified as 'green' according to the Royal Marsden Hospital 'Stop-light' system. 48 (31.2%) were classified as 'orange' and 18 (11.7%) were classified as red, qualifying for automatic referral to clinical genetics. Conclusions A significant proportion of patients diagnosed with cancer in OLCHC may benefit from referral to clinical genetics and screening for underlying cancer predisposition syndromes.
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