The sensitivity of magnetic resonance imaging (MRI) depends strongly on nuclear spin polarisation and, motivated by this observation, dynamical nuclear spin polarisation has recently been applied to enhance MRI protocols (Kurhanewicz et al 2011 Neoplasia 13 81). Nuclear spins associated with the 13 C carbon isotope (nuclear spin I=1/2) in diamond possess uniquely long spin lattice relaxation times (Reynhardt and High 2011 Prog. Nucl. Magn. Reson. Spectrosc. 38 37). If they are present in diamond nanocrystals, especially when strongly polarised, they form a promising contrast agent for MRI. Current schemes for achieving nuclear polarisation, however, require cryogenic temperatures.Here we demonstrate an efficient scheme that realises optically induced 13 C nuclear spin hyperpolarisation in diamond at room temperature and low ambient magnetic field. Optical pumping of a nitrogen-vacancy centre creates a continuously renewable electron spin polarisation which can be transferred to surrounding 13 C nuclear spins. Importantly for future applications we also realise polarisation protocols that are robust against an unknown misalignment between magnetic field and crystal axis.
Highly sensitive nuclear spin detection is crucial in many scientific areas including nuclear magnetic resonance spectroscopy (NMR), imaging (MRI) and quantum computing. The
Nitrogen vacancy (NV) centers in diamond have been used as ultrasensitive magnetometers to perform nuclear magnetic resonance (NMR) spectroscopy of statistically polarized samples at 1–100 nm length scales. However, the spectral linewidth is typically limited to the kHz level, both by the NV sensor coherence time and by rapid molecular diffusion of the nuclei through the detection volume which in turn is critical for achieving long nuclear coherence times. Here we provide a blueprint supported by detailed theoretical analysis for a set-up that combines a sensitivity sufficient for detecting NMR signals from nano- to micron-scale samples with a spectral resolution that is limited only by the nuclear spin coherence, i.e. comparable to conventional NMR. Our protocol detects the nuclear polarization induced along the direction of an external magnetic field with near surface NV centers using lock-in detection techniques to enable phase coherent signal averaging. Using the NV centers in a dual role of NMR detector and optical hyperpolarization source to increase signal to noise, and in combination with Bayesian inference models for signal processing, nano/microscale NMR spectroscopy can be performed on sample concentrations in the micromolar range, several orders of magnitude better than the current state of the art.
Nuclear
spin hyperpolarization provides a promising route to overcome
the challenges imposed by the limited sensitivity of nuclear magnetic
resonance. Here we demonstrate that dissolution of spin-polarized
pentacene-doped naphthalene crystals enables transfer of polarization
to target molecules via intermolecular cross-relaxation at room temperature
and moderate magnetic fields (1.45 T). This makes it possible to exploit
the high spin polarization of optically polarized crystals, while
mitigating the challenges of its transfer to external nuclei. With
this method, we inject the highly polarized mixture into a benchtop
NMR spectrometer and observe the polarization dynamics for target 1H nuclei. Although the spectra are radiation damped due to
the high naphthalene magnetization, we describe a procedure to process
the data to obtain more conventional NMR spectra and extract the target
nuclei polarization. With the entire process occurring on a time scale
of 1 min, we observe NMR signals enhanced by factors between −200
and −1730 at 1.45 T for a range of small molecules.
The realisation of optically detected magnetic resonance via nitrogen vacancy centers in diamond faces challenges at high magnetic fields which include growing energy consumption of control pulses as well as decreasing sensitivities. Here we address these challenges with the design of shaped pulses in microwave control sequences that achieve orders magnitude reductions in energy consumption and concomitant increases in sensitivity when compared to standard top-hat microwave pulses. The method proposed here is general and can be applied to any quantum sensor subjected to pulsed control sequences.We consider the detection of nuclear spins at a strong magnetic field B z 1 T. If the Rabi frequency of the MW driving field is limited, then, for sufficiently high B z , nuclear spins complete several oscillations during a π-pulse. Now we analyse the reduction in sensitivity due to this effect. The Hamiltonian of an NV-nucleus system isHere, S z = |1 1|−|−1 −1|, S x = 1/ √ 2(|1 0|+|−1 0|+H.c.), D = (2π) × 2.87 GHz, γ e ≈ −(2π) × 28.024 GHz/T and A is the hyperfine vector of the NV-nucleus interaction [36]. For B z 1 T, the NV energy splitting between the |0 ↔ | ± 1 arXiv:1805.01741v2 [quant-ph] 31 Oct 2018Here F z (t) is the modulation function that appears as a consequence of the MW pulse sequence, ω n is the nuclear resonance frequency, and A ⊥ x,y are electron-nucleus coupling constants (see Appendix A). We consider periodic pulse sequences of period T such that F z (t) = l f l cos (lω m t) where ω m = 2π T and f l = 2 T T 0 F z (s) cos (lω m s) ds. Examples of these sequences are those of the XY family [37,38] or more sophisticated schemes [17,[39][40][41][42][43][44][45]. For kω m = ω n (resonance condition with the kth harmonic, i.e. for l = k ) Eq. (2) is
Magnetic resonance imaging of 13 C-labeled metabolites enhanced by parahydrogen-induced polarization (PHIP) enables real-time monitoring of processes within the body. We introduce a robust, easily implementable technique for transferring parahydrogen-derived singlet order into 13 C magnetization using adiabatic radio frequency sweeps at microtesla fields. We experimentally demonstrate the applicability of this technique to several molecules, including some molecules relevant for metabolic imaging, where we show significant improvements in the achievable polarization, in some cases reaching above 60% nuclear spin polarization. Furthermore, we introduce a site-selective deuteration scheme, where deuterium is included in the coupling network of a pyruvate ester to enhance the efficiency of the polarization transfer. These improvements are enabled by the fact that the transfer protocol avoids relaxation induced by strongly coupled quadrupolar nuclei.
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