Abstract-High Efficiency Video Coding (HEVC) is the latest joint standardization effort of ITU-T WP 3/16 and ISO/IEC JTC 1/SC 29/WG 11. The resultant standard will be published as twin text by ITU-T and ISO/IEC; in the latter case, it will also be known as MPEG-H Part 2. This paper describes the block partitioning structure of the draft HEVC standard and presents the results of an analysis of coding efficiency and complexity. Of the many new technical aspects of HEVC, the block partitioning structure has been identified as representing one of the most significant changes relative to previous video coding standards. In contrast to the fixed size 16×16 macroblock structure of H.264/AVC, HEVC defines three different units according to their functionalities. The coding unit defines a region sharing the same prediction mode, e.g., intra and inter, and it is represented by the leaf node of a quadtree structure. The prediction unit defines a region sharing the same prediction information. The transform unit, specified by another quadtree, defines a region sharing the same transformation. This paper introduces technical details of the block partitioning structure of HEVC with an emphasis on the method of
This paper proposes a novel video compression scheme based on a highly flexible hierarchy of unit representation which includes three block concepts: coding unit (CU), prediction unit (PU), and transform unit (TU). This separation of the block structure into three different concepts allows each to be optimized according to its role; the CU is a macroblock-like unit which supports region splitting in a manner similar to a conventional quadtree, the PU supports nonsquare motion partition shapes for motion compensation, while the TU allows the transform size to be defined independently from the PU. Several other coding tools are extended to arbitrary unit size to maintain consistency with the proposed design, e.g., transform size is extended up to 64×64 and intraprediction is designed to support an arbitrary number of angles for variable block sizes. Other novel techniques such as a new noncascading interpolation filter design allowing arbitrary motion accuracy and a leaky prediction technique using both open-loop and closed-loop predictors are also introduced. The video codec described in this paper was a candidate in the competitive phase of the high-efficiency video coding (HEVC) standardization work. Compared to H.264/AVC, it demonstrated bitrate reductions of around 40% based on objective measures and around 60% based on subjective testing with 1080p sequences. It has been partially adopted into the first standardization model of the collaborative phase of the HEVC effort.
Hypoxia-inducible factor-1 alpha (HIF1A) is an important transcription factor for angiogenesis. Recent studies have used the protein transduction domain (PTD) to deliver genes, but the PTD has not been used to induce the expression of HIF1A. This study aimed at using a novel PTD (Hph-1-GAL4; ARVRRRGPRR) to overexpress the HIF1A and identify the effects on angiogenesis in vitro and in vivo. Overexpression of HIF1A was induced using Hph-1-GAL4 in human umbilical vein/vascular endothelium cells (HUVEC). The expression levels of genes were analyzed by the quantitative real-time polymerase chain reaction (qPCR) after 2 and 4 days, respectively. An in vitro tube formation was performed using Diff-Quik staining. HIF1A and Hph-1-GAL4 were injected subcutaneously into the ventral area of each 5-week-old mouse. All of the plugs were retrieved after 1 week, and the gene expression levels were evaluated by qPCR. Each Matrigel plug was evaluated using the hemoglobin assay and hematoxylin and eosin (HE) staining. The expression levels of HIF1A and HIF1A target genes were significantly higher in HIF1A-transfected HUVEC than in control HUVEC in vitro. In the in vivo Matrigel plug assay, the amount of hemoglobin was significantly higher in the HIF1A-treatment group than in the PBS-treatment group. Blood vessels were identified in the HIF1A-treatment group. The expression levels of HIF1A, vascular endothelial growth factor (Vegf), and Cd31 were significantly higher in the HIF1A-treatment group than in the PBS-treatment group. These findings suggest that using Hph-1-G4D to overexpress HIF1A might be useful for transferring genes and regenerating tissues.
In this paper, coding efficiency improvement of HEVC using asymmetric motion partitioning (AMP) is provided based on HM-6.0. AMP allows asymmetric shape partition mode of prediction unit (PU) for inter prediction. AMP improves the coding efficiency, since irregular image patterns, which otherwise would be constrained to being represented by a smaller symmetric partition, can now be more efficiently represented without requiring further splitting. For encoder speed up, additional conditions are checked before doing motion estimation for each motion partitions. If the certain conditions are met, additional motion estimation, which is main source of encoder complexity for AMP, can be skipped. Experimental results demonstrate that AMP with encoding speed-up shows 0.8% coding efficiency improvement with 14% encoding time increase. Especially for videoconference sequences, coding efficiency improvement reaches to 1.4%. Index Terms-asymmetric motion partition (AMP), High Efficiency Video Coding (HEVC), video coding
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