Summary. The ca.se records and results of investigations of two niale.s witb partial forms of hyposonadotrophic hypoyonadisin are described. In one there was as.sociated cryptorchidisni. normal plitsina levels, metabolic L-learaiit'e rate and p]a.siiia protein binding of testosterone, jet clinical features of androjjen deficiency were marked and these responded poorly to chorionic gotiadotrophin but well to androgen therapy. A degree of resistance to the action of testosterone is postulated. In the .second patient both goiiadotrophins appeared to l)e deficient, yet chorionic gonadotrophin therapy alone produced speriiiatogenesi.s. The iiTiportance of preliminary HCC therapy in the treatment of infertility in patients with hypogonadotrophic Iiypogonadism ia .stressed. INTRODUGTION.Hypogonadotiophic liypogonadism muy occur as an idiopathic disorder or it may result from surgical, neophistic or iiiHltrative lesions of the anterior pituitary or hypothalainus eitlier prior to or following puberty. The idiopathic form may be familial and may ha\e certain associations; hyposmia, perceptive deafness, colour blindness, skeletal deformities, gynaecomastia, intellectual retardation (Kallmann, SchoeTifeld and Harrera, 1944), interstitial cell resistance to the action of chorionic gonadotropliiii (HGG) and undeseended testes (Bardin, Ross, Rifkind, Gargille and Lipsett, 1969). The associated nervous defects, the findings in a numlier of cases of malformutions of tlie rhiuencephulon (Ganthier, 1960) and of abnormal hypothalamic function (Boyar. Finkelstein, Kupen and Weitzman, 1971) and the possible response of one patient to prolonged clomiphene therapy (Boyur, 1969) tend to indicate an underlying abnormality above the pituitary ghmd in the central nervous system. Thn.s, the pos.siijility arises that distjrdered formation or secretion of the hiteinising hormone releasing hormone (LRFI) may be found at least in some patients. Recently, Naftolin, Harris and Bobrow (1971) infused LRH into two brothers with tlie auo.smic form of bypogonadotrophic hypogonadisni and, while tliere were small rises in plasma
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