Objectives The aim of the present study was to assess the prescriptions of patients who were admitted to the orthopedics and traumatology outpatient clinic of a tertiary care hospital according to the WHO prescribing indicators. Patients and methods Between January 2020 and March 2020, a total of 1,024 patients (273 males, 751 females; mean age: 51.9±13.9 years; range, 19 to 103 years) were included in the study. Only patients who were prescribed drugs and 18 years of age or older were included in the study. The WHO core prescribing indicators were utilized for the assessment of rational drug use. The WHO prescribing indicators percentages between the age categories were analyzed. The average number of drugs between the age categories was also examined. Results The average number of drugs per encounter was 2.9. The percentage of encounters with an antibiotic prescribed was 2.6% and with an injection prescribed was 10.7%. The percentage of drugs prescribed from essential drugs list was 33.8%. There were no prescriptions consisting generic name of drugs (0%). Polypharmacy was significantly higher in the ≥65 age group compared to the 18-44 age group (p=0.001). Conclusion The percentage of encounters with an antibiotic and injection prescribed were optimal according to WHO standards, while the average number of drugs per encounter was higher than the WHO ideal ranges. Unfortunately, the parameters such as the percentage of prescribing with generic name and from essential drug list was far more behind the optimal range.
ÖzPurpose: The aim of the present study is to determine the frequency and severity of possible drug-drug interactions (DDIs) in the prescriptions of patients who admitted to the orthopedics and traumatology outpatient clinics. Materials and Methods: This cross-sectional, retrospective study analyzed the prescription data of patients that admitted to orthopedics and traumatology outpatient clinics of a tertiary care hospital from January 1, 2020 to February 15, 2020. The severity of DDIs was interpreted using the Lexi-comp® drug interaction database. Relationship between the presence of DDIs and the number of prescribed drugs were evaluated. Results: Out of 753 patient data evaluated, a total of 2248 drugs were prescribed. Among 669 polypharmacy patients, 293 (43.8%) patients had one or more potential DDIs. A total of 437 DDIs were detected of which 300 (68.6%) were D, 82 (18.8%) were X, 49 (11.2%) were C and 6 (1.4%) were B risk category interactions. The most common DDIs were between systemic Diclofenac and topical Diclofenac, (14.4%) The presence of potential DDIs was significantly associated with adult age and female gender. Conclusion:Although, the severity of the potential DDIs in orthopedics and traumatology outpatient clinics were generally moderate and manageable, it is crutial for physicians to be aware of the interactions between the most frequently prescribed drugs in orthopedics and traumatology outpatient clinics, monitor patients for the safe use of drugs. Amaç: Bu çalışmanın amacı, ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçetelerinde olası ilaçilaç etkileşimlerinin sıklığını ve şiddetini belirlemektir. Gereç ve Yöntem: Bu kesitsel retrospektif çalışma, 1 Ocak 2020-15 Şubat 2020 tarihleri arasında üçüncü basamak bir hastanenin ortopedi ve travmatoloji polikliniklerine başvuran hastaların reçete verilerini analiz etti. İlaç-ilaç etkileşimlerinin şiddeti, Lexi-comp® ilaç etkileşimi veri tabanı kullanılarak yorumlandı. İlaç-ilaç etkileşimi varlığı ile reçetelenmiş ilaç sayısı arasındaki ilişki değerlendirildi. Bulgular: Değerlendirilen 753 hasta verisinde toplam 2248 ilaç reçete edildi. 669 polifarmasi hastasından, 293 (%43.8) hastanın bir veya daha fazla potansiyel ilaç-ilaç etkileşimi vardı. 300'ü (%68.6) D, 82'si (%18.8) X, 49'u (%11.2) C ve 6'sı (%1.4) B risk kategorisi etkileşimleri olmak üzere toplam 437 ilaç-ilaç etkileşimi tespit edildi. En sık ilaç-ilaç etkileşimleri sistemik diklofenak ve topical diklofenak arasındaydı (%14.4). Olası ilaç-ilaç etkileşimlerinin varlığı erişkin yaş ve kadın cinsiyet ile anlamlı olarak ilişkiliydi. Sonuç: Ortopedi ve travmatoloji polikliniklerinde olası ilaç-ilaç etkileşimlerinin şiddeti genel olarak orta düzeyde ve yönetilebilir olsa da, ortopedi ve travmatoloji polikliniklerinde en sık reçete edilen ilaçlar arasındaki etkileşimlerden haberdar olmak ve ilaçların güvenli kullanımı için hastaları izlemek hekimler açısından önem taşımaktadır.
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