With an early diagnosis of mucormycosis by clinical findings, culture, or tissue biopsy, and aggressive treatment consisting of administration of liposomal amphotericin B and surgical resection of all infected tissue, excellent results are achieved.
Purpose Idiopathic juvenile osteoporosis (IJO) is a rare condition in children, characterized by bone pain, long bone and vertebral fractures. Previously, IJO bone was solely characterized by histomorphometry and quantitative computed tomography. The goal of this study is to describe IJO bone composition. Materials and Methods Fourier transform infrared imaging (FTIRI), a vibrational spectroscopic technique providing spatially resolved images of chemical composition, was used to determine whether iliac crest biopsies from children with IJO differed in composition from and age- and sex-matched controls, and, as a secondary analysis, whether IJO-bone showed the same disease dependent change in composition as do iliac crest bone biopsies from women with postmenopausal osteoporosis (PMO). Wilcoxon rank-tests and linear regressions were used to analyze FTIRI variables (mineral-to-matrix ratio, carbonate-to-phosphate ratio, crystallinity, acid-phosphate substitution, collagen maturity) and their individual pixel distributions (Heterogeneity). Results Mineral-to-matrix ratio was comparable in IJO and age-matched controls. Contrastingly, collagen maturity (also known as collagen cross-link ratio) was higher in cortical and cancellous IJO bone compared to juvenile controls. Acid-phosphate substitution was greater in IJO cancellous bone than in age-matched controls, suggesting IJO bone mineral is formed more recently, reflecting a slower mineralization process. This agrees with findings of increased heterogeneity for mineral-to-matrix and collagen maturity ratios in IJO cancellous bone. There were negative correlations between cancellous collagen maturity and previously reported histomorphometric bone formation markers. There were no correlations with indices of remodeling. Conclusions IJO bone, similar to PMO bone, had elevated collagen maturity relative to its age-matched controls. This emphasizes the importance of the collagen matrix for bone health. IJO bone differed from PMO bone as IJO bone contains more recently formed mineral than age-matched controls but has a more mature matrix, whereas in PMO-bone both mineral and matrix have older characteristics.
e 399Objective: The body mass index (BMI) is well-established in terms of cardiovascular risk, yet it is still underused in clinical practice and not included in cardiovascular risk scores. Our objective was to relate the BMI to the risk score for atherosclerotic cardiovascular disease (ASCVD), based on the joint recommendations of the American College of Cardiology and the American Heart Association for assessment of cardiovascular risk.Design and method: Retrospective analysis of clinical and laboratory data in a population of 210 patients, over 65 years of age, followed in a primary care center. We valued the data needed to calculate the cardiovascular risk at 10 years, available at http://tools.cardiosource.org/ASCVD-Risk-Estimator/: ethnicity, gender, systolic blood pressure (SBP-mmHg), treatment for hypertension (TxHT) irrespective of the therapeutic agent, diabetes mellitus (DM), smoking (SK), total cholesterol (TCmg/dl) and HDL cholesterol (HDL-mg/dl). BMI was calculated for every patient. Two groups were created according to of BMI less than 30 Kg/m 2 (Group 0), or BMI equal to or greater than 30 Kg/m 2 (Group 1). The two groups were compared (SPSS, Chicago Illinois, version 20) as to age, risk factors and the 10-Year ASCVD risk score (%). Linear correlation was performed between BMI and TC, HDL, PAS and the 10-Year ASCVD risk score.Results: All patients were of Caucasian ethnicity. The comparison between the two groups is expressed in the table below. Linear correlations were: BMI vs CT: R 2 = 0.002; BMI vs HDL: R 2 = 0.006; BMI vs PAS: R 2 = 0.002; BMI vs 10-Year ASCVD risk score: R 2 = 0.061 (see graph). Conclusions:In this population, the presence of obesity relates to the presence of DM, to a greater therapeutic use and it appears to clearly influence the cardiovascular risk. BMI has a better correlation with ASCVD than the risk factors studied. excretion and systolic blood pressure (BP) (r 2 = 0.13 p < 0.001) as well as diastolic BP (r 2 = 0.07 p < 0.001) and a weak negative correlation with nadir CD4(+) count (r 2 = 0.02 p < 0.05). 0263-6352Conclusions: Hypertension, DM and hypercholesterolemia were associated with microalbuminuria and high-normal albuminuria in HIV-1(+) patients. A positive correlation was observed among albumin urinary excretion and systolic and diastolic blood pressure in these subjects.Objective: To investigate the cardiovascular profile and its relation to reported cardiovascular diseases and death in the main hospitals in the Emirate. Design and method:It is a retrospective case control cohort. Two reports were generated from the electronic medical records and merged to identify patients who did WEQAYA, the national preventive screening program, and were admitted in the hospitals from 2008. Included patients were those who were only reported of the studies outcomes after at least a month of their WEQAYA screening. Not all WEQAYA data was accessed, only around100,000 patients, and from them only 5129 admissions could be tracked. SPSS version 21 was used in analysis and regres...
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